Overview

Description

  • NatureSynthetic
  • Amino Acid Sequence
    • SpeciesHuman
    • SequenceC-KARSISLKLDSEE
    • Amino acids1232 to 1244

Associated products

Specifications

Our Abpromise guarantee covers the use of ab45570 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-NIR2 antibody (ab22823)

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

General Info

  • Alternative names
    • DRES9
    • Drosophila retinal degeneration B
    • Drosophila retinal degeneration B homolog
    • FLJ44997
    • membrane-associated 1
    • Membrane-associated phosphatidylinositol transfer protein 1
    • NIR 2
    • NIR-2
    • NIR2
    • OTTHUMP00000236414
    • OTTHUMP00000236415
    • Phosphatidylinositol transfer protein
    • phosphatidylinositol transfer protein membrane associated
    • PITM1_HUMAN
    • PITPNM
    • PITPnm 1
    • Pitpnm1
    • PYK2 N terminal domain interacting receptor 2
    • Pyk2 N-terminal domain-interacting receptor 2
    • RD 9
    • RD9
    • RDGB
    • RDGB1
    • RDGBA1
    • retinal degeneration B alpha 1
    see all
  • FunctionRegulates RHOA activity, and plays a role in cytoskeleton remodeling. Necessary for normal completion of cytokinesis. Plays a role in maintaining normal diacylglycerol levels in the Golgi apparatus. Binds phosphatidyl inositol phosphates (in vitro). May catalyze the transfer of phosphatidylinositol and phosphatidylcholine between membranes (By similarity). Necessary for maintaining the normal structure of the endoplasmic reticulum and the Golgi apparatus. Required for protein export from the endoplasmic reticulum and the Golgi. Binds calcium ions.
  • Tissue specificityUbiquitous.
  • Sequence similaritiesBelongs to the PtdIns transfer protein family. PI transfer class IIA subfamily.
    Contains 1 DDHD domain.
  • Post-translational
    modifications
    Phosphorylated on multiple sites by CDK1 at the onset of mitosis. Phosphorylation facilitates dissociation from the Golgi complex and is required for interaction with PLK1.
    Phosphorylated on threonine residues upon treatment with oleic acid.
    Phosphorylated on tyrosine residues by PTK2B.
  • Cellular localizationCytoplasm. Golgi apparatus > Golgi stack membrane. Endoplasmic reticulum membrane. Lipid droplet. Cleavage furrow. Midbody. Peripheral membrane protein associated with Golgi stacks in interphase cells. A minor proportion is associated with the endoplasmic reticulum. Associated with lipid droplets. Dissociates from the Golgi early on in mitosis and localizes to the cleavage furrow and midbody during cytokinesis.
  • Information by UniProt

References for Human NIR2 peptide (ab45570)

ab45570 has not yet been referenced specifically in any publications.

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