Overview

Description

  • NatureSynthetic
  • Amino Acid Sequence
    • SpeciesHuman
    • SequenceIASQHPNTRIGVFLCGPEALAETLSKQSISNSESGPRGVHFIFNKENF

Associated products

Specifications

Our Abpromise guarantee covers the use of ab111671 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-NOX2/gp91phox antibody (ab80508)

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.

General Info

  • Alternative names
    • AMCBX2
    • CGD
    • CGD91-phox
    • CY24B_HUMAN
    • CYBB
    • Cytochrome b 245, beta polypeptide
    • Cytochrome b(558) beta chain
    • Cytochrome b(558) subunit beta
    • Cytochrome b-245 heavy chain
    • Cytochrome b558 subunit beta
    • GP91 PHOX
    • gp91-1
    • gp91-phox
    • GP91PHOX
    • Heme-binding membrane glycoprotein gp91phox
    • NADPH oxidase 2
    • Neutrophil cytochrome b 91 kDa polypeptide
    • NOX2
    • p22 phagocyte B-cytochrome
    • P91 PHOX
    • p91-PHOX
    • Superoxide-generating NADPH oxidase heavy chain subunit
    see all
  • FunctionCritical component of the membrane-bound oxidase of phagocytes that generates superoxide. It is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membrane to molecular oxygen on the exterior. Also functions as a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes. It participates in the regulation of cellular pH and is blocked by zinc.
  • Involvement in diseaseDefects in CYBB are a cause of chronic granulomatous disease X-linked (XCGD) [MIM:306400]. Chronic granulomatous disease is a genetically heterogeneous disorder characterized by the inability of neutrophils and phagocytes to kill microbes that they have ingested. Patients suffer from life-threatening bacterial/fungal infections.
  • Sequence similaritiesContains 1 FAD-binding FR-type domain.
    Contains 1 ferric oxidoreductase domain.
  • Post-translational
    modifications
    Glycosylated.
  • Cellular localizationMembrane.
  • Information by UniProt

References for Human NOX2/gp91phox peptide (ab111671)

ab111671 has not yet been referenced specifically in any publications.

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