Overview

Description

  • Nature
    Synthetic
  • Amino Acid Sequence
    • Species
      Human

Associated products

Specifications

Our Abpromise guarantee covers the use of ab39823 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Western blot

    Blocking - Blocking peptide for Anti-Noxa antibody (ab36833)

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: 0.02% Sodium Azide
    Constituents: 0.1% BSA, PBS, pH 7.2

General Info

  • Alternative names
    • Adult T cell leukemia derived PMA responsive
    • APR
    • APR_HUMAN
    • ATL-derived
    • Immediate early response protein APR
    • Immediate-early-response protein APR
    • NOXA
    • Phorbol 12 myristate 13 acetate induced protein 1
    • Phorbol-12-myristate-13-acetate-induced protein 1
    • PMA induced protein 1
    • PMA-induced protein 1
    • PMA-responsive gene
    • Pmaip1
    • Protein Noxa
    see all
  • Function
    Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1 (By similarity). Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1.
  • Tissue specificity
    Highly expressed in adult T-cell leukemia cell line.
  • Sequence similarities
    Belongs to the PMAIP1 family.
  • Domain
    The BH3 motif is essential for pro-apoptotic activity.
  • Cellular localization
    Mitochondrion.
  • Information by UniProt

References

ab39823 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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