The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Gene 21 protein
Homologous to yeast nitrogen permease
Homologous to yeast nitrogen permease (candidate tumor suppressor)
Nitrogen permease regulator 2-like protein
Nitrogen permease regulator-like 2 (S. cerevisiae)
NPR like 2
Tumor suppressor candidate 4
TUSC 4 protein
FunctionSuppresses Src-dependent tyrosine phosphorylation and activation of PDPK1 and its downstream signaling. Down-regulates PDPK1 kinase activity by interfering with tyrosine phosphorylation at the Tyr-9 Tyr-373 and Tyr-376 residues. May act as a tumor suppressor. Suppresses cell growth and enhanced sensitivity to various anticancer drugs.
Tissue specificityMost abundant in skeletal muscle, followed by brain, liver and pancreas, with lower amounts in lung, kidney, placenta and heart. Expressed in most lung cancer cell lines tested.