Overview

Description

  • Nature
    Synthetic
  • Amino Acid Sequence
    • Species
      Human
    • Sequence
      ERLENDPNIIICWK
    • Amino acids
      367 to 380

Specifications

Our Abpromise guarantee covers the use of ab22958 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

General Info

  • Alternative names
    • 2810446G01Rik
    • G21 protein
    • Gene 21 protein
    • Homologous to yeast nitrogen permease
    • Homologous to yeast nitrogen permease (candidate tumor suppressor)
    • Nitrogen permease regulator 2-like protein
    • Nitrogen permease regulator-like 2 (S. cerevisiae)
    • NPR 2L
    • NPR L2
    • NPR like 2
    • NPR2
    • NPR2 like
    • NPR2-like protein
    • NPR2L
    • NPRL 2
    • NPRL2
    • NPRL2_HUMAN
    • Tumor suppressor candidate 4
    • TUSC 4
    • TUSC 4 protein
    • TUSC4
    • TUSC4 protein
    see all
  • Function
    Suppresses Src-dependent tyrosine phosphorylation and activation of PDPK1 and its downstream signaling. Down-regulates PDPK1 kinase activity by interfering with tyrosine phosphorylation at the Tyr-9 Tyr-373 and Tyr-376 residues. May act as a tumor suppressor. Suppresses cell growth and enhanced sensitivity to various anticancer drugs.
  • Tissue specificity
    Most abundant in skeletal muscle, followed by brain, liver and pancreas, with lower amounts in lung, kidney, placenta and heart. Expressed in most lung cancer cell lines tested.
  • Sequence similarities
    Belongs to the NPR2 family.
  • Information by UniProt

References

ab22958 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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