Overview

Description

  • NatureSynthetic
  • Amino Acid Sequence
    • SpeciesHuman
    • SequenceC-PFSSDLQKTFEIEL
    • Amino acids638 to 651

Associated products

Specifications

Our Abpromise guarantee covers the use of ab22990 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-NUMB antibody (ab4147)

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

General Info

  • Alternative names
    • c14_5527
    • C14orf41
    • FLJ31314
    • h Numb
    • h-Numb
    • Numb
    • Numb homolog
    • Numb homolog (Drosophila)
    • Numb protein homolog
    • NUMB_HUMAN
    • Protein numb homolog
    • Protein S171
    • S171
    see all
  • FunctionPlays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. May also mediate local repair of brain ventricular wall damage.
  • Sequence similaritiesContains 1 PID domain.
  • Post-translational
    modifications
    Isoform 1 and isoform 2 are ubiquitinated by LNX leading to their subsequent proteasomal degradation (By similarity). Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation.
  • Cellular localizationMembrane.
  • Information by UniProt

References for Human NUMB peptide (ab22990)

ab22990 has not yet been referenced specifically in any publications.

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