Overview

Description

  • NatureSynthetic

Specifications

Our Abpromise guarantee covers the use of ab37499 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Information available upon request.

General info

  • Alternative names
    • CAG 3A
    • CAG 3A
    • CAG3A
    • CAG3A
    • CTG 3a
    • CTG 3a
    • CTG3a
    • CTG3a
    • NBL
    • NBL
    • NUMB Drosophilia Homolog Like
    • NUMB Drosophilia Homolog Like
    • Numb homolog (Drosophila) like
    • Numb homolog like
    • Numb like protein
    • NUMB R
    • Numb-like protein
    • Numb-R
    • Numb-related gene
    • Numb-related protein
    • NUMBL
    • NUMBL_HUMAN
    • NUMBLIKE
    • NUMBR
    • NUMBR
    • TNRC 23
    • TNRC 23
    • TNRC23
    • TNRC23
    • Trinucleotide repeat-containing gene 23
    see all
  • FunctionPlays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of NF-kappa-B activation is mediated at least in part, by preventing MAP3K7IP2 to interact with polyubiquitin chains of TRAF6 and RIPK1 and by stimulating the 'Lys-48'-linked polyubiquitination and degradation of TRAF6 in cortical neurons.
  • Sequence similaritiesContains 1 PID domain.
  • DomainThe PTB domain is necessary for the inhibition of MAP3K7IP2-mediated activation of NF-kappa-B.
  • Cellular localizationCytoplasm. Symmetrically distributed throughout the cytoplasm in non dividing neuroblasts of the CNS.
  • Target information above from: UniProt accession Q9Y6R0 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

References for Human NUMBL peptide (ab37499)

ab37499 has not yet been referenced specifically in any publications.

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