Overview

Description

  • NatureSynthetic
  • Amino Acid Sequence
    • SpeciesHuman
    • SequenceSLPGSGLPSVGSIRPPHGLLKSPSAAAAAPLGGGGGGSGASGGFQHWGGM

Associated products

Specifications

Our Abpromise guarantee covers the use of ab111666 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-Olig2 antibody (ab42453)

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.

General Info

  • Alternative names
    • Basic domain helix loop helix protein class B 1
    • Basic helix loop helix protein class B 1
    • BHLHB
    • bHLHB1
    • bHLHe19
    • Class B basic helix loop helix protein 1
    • Class B basic helix-loop-helix protein 1
    • class E basic helix loop helix protein 19
    • Class E basic helix-loop-helix protein 19
    • Human protein kinase C binding protein RACK17
    • Olig2
    • OLIG2_HUMAN
    • Oligo2
    • Oligodendrocyte lineage transcription factor 2
    • Oligodendrocyte specific bHLH transcription factor 2
    • Oligodendrocyte transcription factor 2
    • OTTHUMP00000067569
    • OTTHUMP00000067570
    • PRKCBP2
    • Protein kinase C binding protein 2
    • Protein kinase C binding protein RACK17
    • Protein kinase C-binding protein 2
    • Protein kinase C-binding protein RACK17
    • RACK17
    see all
  • FunctionRequired for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain. Cooperates with OLIG1 to establish the pMN domain of the embryonic neural tube. Antagonist of V2 interneuron and of NKX2-2-induced V3 interneuron development.
  • Tissue specificityExpressed in the brain, in oligodendrocytes. Strongly expressed in oligodendrogliomas, while expression is weak to moderate in astrocytomas. Expression in glioblastomas highly variable.
  • Involvement in diseaseNote=A chromosomal aberration involving OLIG2 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(14;21)(q11.2;q22) with TCRA.
  • Sequence similaritiesContains 1 basic helix-loop-helix (bHLH) domain.
  • DomainThe bHLH is essential for interaction with NKX2-2.
  • Cellular localizationNucleus. Cytoplasm. The NLS contained in the bHLH domain could be masked in the native form and translocation to the nucleus could be mediated by interaction either with class E bHLH partner protein or with NKX2-2.
  • Information by UniProt

References for Human Olig2 peptide (ab111666)

ab111666 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab111666.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"