Overview

Description

  • Nature
    Synthetic
  • Amino Acid Sequence
    • Species
      Human
    • Sequence
      C-DVRQWATSSLSWL
    • Amino acids
      424 to 436

Associated products

Specifications

Our Abpromise guarantee covers the use of ab23156 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-ORC4L antibody - ChIP Grade (ab9641)

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

General Info

  • Alternative names
    • Origin recognition complex, subunit 4, S. cerevisiae, homolog of
    • FLJ46668
    • HSORC4
    • ORC 4
    • ORC 4L
    • ORC 4P
    • ORC4
    • ORC4_HUMAN
    • ORC4L
    • ORC4L protein
    • ORC4P
    • Origin recognition complex subunit 4
    • Origin recognition complex subunit 4 (yeast homolog) like
    • Origin recognition complex subunit 4 like
    • Origin recognition complex subunit 4 like (yeast)
    • origin recognition complex, subunit 4 homolog
    • Origin recognition complex, subunit 4, S. cerevisiae, homolog-like
    see all
  • Function
    Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.
  • Involvement in disease
    Defects in ORC4 are the cause of Meier-Gorlin syndrome type 2 (MGORS2) [MIM:613800]. MGORS2 is a syndrome characterized by bilateral microtia, aplasia/hypoplasia of the patellae, and severe intrauterine and postnatal growth retardation with short stature and poor weight gain. Additional clinical findings include anomalies of cranial sutures, microcephaly, apparently low-set and simple ears, microstomia, full lips, highly arched or cleft palate, micrognathia, genitourinary tract anomalies, and various skeletal anomalies. While almost all cases have primordial dwarfism with substantial prenatal and postnatal growth retardation, not all cases have microcephaly, and microtia and absent/hypoplastic patella are absent in some. Despite the presence of microcephaly, intellect is usually normal.
  • Sequence similarities
    Belongs to the ORC4 family.
  • Cellular localization
    Nucleus.
  • Information by UniProt

References

ab23156 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab23156.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

Sign up