Overview

Description

  • NatureSynthetic
  • Amino Acid Sequence
    • SpeciesHuman
    • SequenceC-KEKQDWSSCPDIF
    • Amino acids407 to 420

Associated products

Specifications

Our Abpromise guarantee covers the use of ab23121 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-OSBP1 antibody (ab5915)

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

General Info

  • Alternative names
    • OSBP
    • OSBP 1
    • OSBP1_HUMAN
    • Oxysterol binding protein 1
    • Oxysterol-binding protein 1
    see all
  • FunctionBinds cholesterol and a range of oxysterols. Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylate ERK1/2, whereas 25-hydroxycholesterol causes its disassembly. Regulates cholesterol efflux by decreasing ABCA1 stability.
  • Tissue specificityWidely expressed.
  • Sequence similaritiesBelongs to the OSBP family.
    Contains 1 PH domain.
  • DomainThe PH and Ala/Gly-rich domains control cholesterol binding without affecting 25-hydroxycholesterol binding.
    The second coiled-coil domain is required for interaction with the tyrosine phosphatase.
  • Cellular localizationCytoplasm. Golgi apparatus membrane. When bound to oxysterols, translocates to the periphery of Golgi membranes.
  • Information by UniProt

References for Human OSBP1 peptide (ab23121)

ab23121 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab23121.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"