Anti-Human Papillomavirus 16 (E7) antibody [716-281] (ab82601)

Overview

  • Product nameAnti-Human Papillomavirus 16 (E7) antibody [716-281]
    See all Human Papillomavirus 16 (E7) primary antibodies
  • Description
    Mouse monoclonal [716-281] to Human Papillomavirus 16 (E7)
  • Specificityab82601 recognizes HPV oncoprotein E7, types 16 and 18 (both monomer and dimer forms by Western blot).
  • Tested applicationsSuitable for: WB, Sandwich ELISAmore details
  • Species reactivity
    Reacts with: Human Papillomavirus (HPV)
  • Immunogen

    HPV oncoprotein E7, type 16.

Properties

Applications

Our Abpromise guarantee covers the use of ab82601 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use at an assay dependent dilution.
Sandwich ELISA Use at an assay dependent dilution.

Target

  • RelevanceE7 protein has both transforming and trans-activating activities. Disrupts the function of host retinoblastoma protein RB1/pRb, which is a key regulator of the cell cycle. Induces the disassembly of the E2F1 transcription factors from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes. Inactivation of the ability of RB1 to arrest the cell cycle is critical for cellular transformation, uncontrolled cellular growth and proliferation induced by viral infection. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication. Interferes with histone deacetylation mediated by HDAC1 and HDAC2, leading to activation of transcription
  • Cellular localizationNuclear
  • Database links
    • Alternative names
      • E7 antibody
      • HPV16 E7 antibody
      • Protein E7 antibody
      • Transforming protein antibody

    References for Anti-Human Papillomavirus 16 (E7) antibody [716-281] (ab82601)

    ab82601 has not yet been referenced specifically in any publications.

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