Anti-Human Papillomavirus 16 (E7) antibody [SPM405] (ab19938)

Overview

  • Product nameAnti-Human Papillomavirus 16 (E7) antibody [SPM405]
    See all Human Papillomavirus 16 (E7) primary antibodies
  • Description
    Mouse monoclonal [SPM405] to Human Papillomavirus 16 (E7)
  • Tested applicationsSuitable for: Flow Cyt, ICC/IFmore details
  • Species reactivity
    Reacts with: Human Papillomavirus (HPV)
  • Immunogen

    Recombinant full length protein (HPV type 16).

  • Positive control
    • Cervical tissue infected with HPV16.

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage bufferPreservative: 0.09% Sodium Azide
    Constituents: 10% PBS, BSA, pH 7.4
  • Concentration information loading...
  • PurityProtein A purified
  • ClonalityMonoclonal
  • Clone numberSPM405
  • IsotypeIgG2a
  • Light chain typekappa
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab19938 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Flow Cyt Use at an assay dependent concentration. ab170191-Mouse monoclonal IgG2a, is suitable for use as an isotype control with this antibody.
ICC/IF Use at an assay dependent concentration.

Target

  • RelevanceE7 protein has both transforming and trans-activating activities. Disrupts the function of host retinoblastoma protein RB1/pRb, which is a key regulator of the cell cycle. Induces the disassembly of the E2F1 transcription factors from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes. Inactivation of the ability of RB1 to arrest the cell cycle is critical for cellular transformation, uncontrolled cellular growth and proliferation induced by viral infection. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication. Interferes with histone deacetylation mediated by HDAC1 and HDAC2, leading to activation of transcription
  • Cellular localizationNuclear
  • Database links
    • Alternative names
      • E7 antibody
      • HPV16 E7 antibody
      • Protein E7 antibody
      • Transforming protein antibody

    References for Anti-Human Papillomavirus 16 (E7) antibody [SPM405] (ab19938)

    ab19938 has not yet been referenced specifically in any publications.

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    The conc of this product is 200 ug/ml. The product can be further diluted 1/50 or 1/100 for sue in ICC/IF and Flow Cytometry. Please note the dilutions has to be optimized by the end user. Try lowest dilution fir...

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"