Overview

Description

  • NatureSynthetic

Specifications

Our Abpromise guarantee covers the use of ab45230 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Information available upon request.

General info

  • Alternative names
    • Mitochondrial intramembrane cleaving protease PARL
    • Mitochondrial intramembrane-cleaving protease PARL
    • P-beta
    • parl
    • PARL_HUMAN
    • Pbeta
    • presenilin associated rhomboid-like
    • Presenilins associated rhomboid-like protein
    • PRO2207
    • PSARL
    • PSARL1
    • PSENIP2
    • RHBDS1
    • Rhomboid 7 homolog 1
    see all
  • FunctionRequired for the control of apoptosis during postnatal growth. Essential for proteolytic processing of an antiapoptotic form of OPA1 which prevents the release of mitochondrial cytochrome c in response to intrinsic apoptoptic signals (By similarity). Promotes changes in mitochondria morphology regulated by phosphorylation of P-beta domain.
  • Sequence similaritiesBelongs to the peptidase S54 family.
  • Post-translational
    modifications
    P-beta is proteolytically processed (beta-cleavage) in a PARL-dependent manner. The cleavage is inhibited when residues Ser-65, Thr-69 and Ser-70 are all phosphorylated.
  • Cellular localizationMitochondrion inner membrane and Nucleus. Translocated into the nucleus by an unknown mechanism.
  • Target information above from: UniProt accession Q9H300 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

References for Human PARL peptide (ab45230)

ab45230 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"