The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Blocking - Blocking peptide for Anti-PAX5 antibody (ab2935)
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
B cell lineage specific activator
B cell lineage specific activator protein
B cell specific activator protein
B cell specific transcription factor
B-cell-specific transcription factor
Paired box 5
Paired box gene 5
Paired box gene 5 (B cell lineage specific activator protein)
Paired box gene 5 (B cell lineage specific activator)
Paired box homeotic gene 5
Paired box protein Pax 5
Paired box protein Pax-5
Paired domain gene 5
Transcription factor PAX 5
May play an important role in B-cell differentiation as well as neural development and spermatogenesis. Involved in the regulation of the CD19 gene, a B-lymphoid-specific target gene.
Involvement in disease
A chromosomal aberration involving PAX5 is a cause of acute lymphoblastic leukemia. Translocation t(9;18)(p13;q11.2) with ZNF521. Translocation t(9;3)(p13;p14.1) with FOXP1. Translocation t(9;12)(p13;p13) with ETV6. Leukemia, acute lymphoblastic, 3
Contains 1 paired domain.
Expressed at early B-cell differentiation, in the developing CNS and in adult testis.