Overview

Description

  • NatureSynthetic
  • Amino Acid Sequence
    • SpeciesHuman
    • SequencePHNSIRSGHGGLN-C
    • Amino acids2 to 14

Associated products

Specifications

Our Abpromise guarantee covers the use of ab23220 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-PAX8 antibody (ab13611)

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

General Info

  • Alternative names
    • OTTHUMP00000158659
    • OTTHUMP00000158660
    • OTTHUMP00000203723
    • OTTHUMP00000203724
    • Paired box 8
    • Paired box gene 8
    • paired box homeotic gene 8
    • Paired box protein Pax 8
    • Paired box protein Pax-8
    • Paired domain gene 8
    • PAX 8
    • PAX8
    • PAX8_HUMAN
    see all
  • FunctionTranscription factor for the thyroid-specific expression of the genes exclusively expressed in the thyroid cell type, maintaining the functional differentiation of such cells.
  • Tissue specificityExpressed in the excretory system, thyroid gland and Wilms tumors.
  • Involvement in diseaseDefects in PAX8 are the cause of congenital hypothyroidism non-goitrous type 2 (CHNG2) [MIM:218700]. CHNG2 is a disease characterized by thyroid dysgenesis, the most frequent cause of congenital hypothyroidism, accounting for 85% of case. The thyroid gland can be completely absent (athyreosis), ectopically located and/or severely hypoplastic. Ectopic thyroid gland is the most frequent malformation, with thyroid tissue being found most often at the base of the tongue.
  • Sequence similaritiesContains 1 paired domain.
  • Developmental stageIn developing excretory system, during thyroid differentiation and in adult thyroid.
  • Cellular localizationNucleus.
  • Information by UniProt

References for Human PAX8 peptide (ab23220)

ab23220 has not yet been referenced specifically in any publications.

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