Overview

Description

  • NatureSynthetic
  • Amino Acid Sequence
    • SpeciesHuman
    • SequenceC-ARAIIREGSLEGS
    • Amino acids644 to 656

Associated products

Specifications

Our Abpromise guarantee covers the use of ab45561 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-Pericentrin 1 antibody (ab19044)

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

General Info

  • Alternative names
    • 85 kDa nucleoporin
    • FLJ12549
    • FROUNT
    • Frount protein
    • Nuclear pore complex protein nucleoporin 85 kDa
    • nuclear pore complex protein nucleoporin Nup75
    • Nuclear pore complex protein Nup85
    • Nucleoporin 85
    • Nucleoporin 85kDa
    • Nucleoporin nucleoporin 85kDa
    • Nucleoporin Nup75
    • Nucleoporin NUP85
    • nucleoporin, 75-KD
    • Nucleoporin85
    • Nup 75
    • NUP 85
    • Nup75
    • nup85
    • NUP85_HUMAN
    • PCN
    • PCNT
    • PCNT 1
    • PCNT, formerly
    • PCNT1
    • Pericentrin
    • Pericentrin, formerly
    • Pericentrin-1
    • Pericentrin1
    see all
  • FunctionEssential component of the nuclear pore complex (NPC) that seems to be required for NPC assembly and maintenance. As part of the NPC Nup107-160 subcomplex plays a role in RNA export and in tethering NUP98/Nup98 and NUP153 to the nucleus. The Nup107-160 complex seems to be required for spindle assembly during mitosis. NUP85 is required for membrane clustering of CCL2-activated CCR2. Seems to be involved in CCR2-mediated chemotaxis of monocytes and may link activated CCR2 to the phosphatidyl-inositol 3-kinase-Rac-lammellipodium protrusion cascade.
  • Sequence similaritiesBelongs to the nucleoporin Nup85 family.
  • Cellular localizationNucleus > nuclear pore complex. Chromosome > centromere > kinetochore. Cytoplasm > cytoskeleton > spindle. Cytoplasm. Nucleus membrane. During mitosis, localizes to the kinetochores and spindle poles. Upon CCl2 stimulation translocates from the cytoplasm to the membrane and colocalizes with CCR2 at the front of migrating cells.
  • Information by UniProt

References for Human Pericentrin 1 peptide (ab45561)

ab45561 has not yet been referenced specifically in any publications.

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