Overview

Description

  • NatureSynthetic
  • Amino Acid Sequence
    • SpeciesHuman
    • SequenceC-KRKRETDDEGEDD
    • Amino acids237 to 249

Associated products

Specifications

Our Abpromise guarantee covers the use of ab23013 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-PHAPI2 / APRIL antibody (ab4224)

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

General Info

  • Alternative names
    • Acidic (leucine rich) nuclear phosphoprotein 32 family member B
    • Acidic leucine rich nuclear phosphoprotein 32 family member B
    • Acidic leucine-rich nuclear phosphoprotein 32 family member B
    • Acidic nuclear phosphoprotein 32 family member B
    • Acidic protein rich in leucines
    • AN32B_HUMAN
    • ANP 32B
    • ANP32B
    • APRIL
    • OTTHUMP0000006377
    • PAL 31
    • PAL31
    • PHAPI 2
    • PHAPI2
    • PHAPI2 protein
    • PHAPI2a
    • Proliferation related acidic leucine rich protein
    • Putative HLA-DR-associated protein I-2
    • Silver stainable protein SSP 29
    • Silver stainable protein SSP29
    • Silver-stainable protein SSP29
    • Ssp 29
    • Ssp29
    see all
  • FunctionMultifunctional protein working as a cell cycle progression factor as well as a cell survival factor. Required for the progression from the G1 to the S phase. Anti-apoptotic protein which functions as a caspase-3 inhibitor. Has no phosphatase 2A (PP2A) inhibitor activity (By similarity). Exhibits histone chaperone properties, stimulating core histones to assemble into a nucleosome.
  • Tissue specificityExpressed in heart, lung, pancreas, prostate and in spleen, thymus and placenta.
  • Sequence similaritiesBelongs to the ANP32 family.
    Contains 4 LRR (leucine-rich) repeats.
    Contains 1 LRRCT domain.
  • DomainHistone binding is mediated by the concave surface of the LRR region.
  • Post-translational
    modifications
    Some glutamate residues are glycylated by TTLL8. This modification occurs exclusively on glutamate residues and results in a glycine chain on the gamma-carboxyl group.
  • Cellular localizationNucleus. Accumulates in the nuclei at the S phase and Cytoplasm. Lacks a nuclear localization signal.
  • Information by UniProt

References for Human PHAPI2 / APRIL peptide (ab23013)

ab23013 has not yet been referenced specifically in any publications.

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