The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Pan hematopoietic expression
Tumor suppressing STF cDNA 6
Tumor suppressing subchromosomal transferable fragment cDNA 6
Tumor suppressing subtransferable candidate 6
RelevancePHEMX belongs to the conserved tetraspanin family of integral membrane proteins, which are thought to form multiprotein networks in the cell membrane in association with multiple protein partners. Tetraspanins have functional roles in cell motility, membrane fusion, proliferation, and adaptive immunity. This gene is one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. PHEMX may play a role in malignancies and disease that involve this region as well as hematopoietic cell function. There are 5 isoforms produced by alternative splicing.
Cellular localizationMembrane; Multi-pass membrane protein
References for Human PHEMX peptide (ab22923)
has not yet been referenced specifically in any publications.
Publishing research using ab22923? Please let us know so that we can cite the reference in this datasheet.
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