Overview

Description

  • Nature
    Synthetic
  • Amino Acid Sequence
    • Species
      Human
    • Sequence
      C-RARQSLGTGTLVS
    • Amino acids
      115 to 127

Associated products

Specifications

Our Abpromise guarantee covers the use of ab45560 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-PHLDA3 antibody (ab22822)

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

General Info

  • Alternative names
    • PHLA3_HUMAN
    • PHLDA 3
    • phlda3
    • Pleckstrin homology like domain family A member 2
    • Pleckstrin homology like domain family A member 3
    • Pleckstrin homology-like domain family A member 3
    • TDAG51/Ipl homolog 1
    • TDAG51/Ipl homologue 1
    • TIH 1
    • TIH1
    see all
  • Function
    p53/TP53-regulated repressor of Akt/AKT1 signaling. Represses AKT1 by preventing AKT1-binding to membrane lipids, thereby inhibiting AKT1 translocation to the cellular membrane and activation. Contributes to p53/TP53-dependent apoptosis by repressing AKT1 activity. Its directs transcription regulation by p53/TP53 may explain how p53/TP53 can negatively regulate AKT1. May acts as a tumor suppressor.
  • Tissue specificity
    Widely expressed with lowest expression in liver and spleen.
  • Sequence similarities
    Belongs to the PHLDA3 family.
    Contains 1 PH domain.
  • Domain
    The PH domain binds phosphoinositides with a broad specificity. It competes with the PH domain of AKT1 and directly interferes with AKT1 binding to phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidylinositol 3,4,5-triphosphate (PIP3), preventing AKT1 association to membrane lipids and subsequent activation of AKT1 signaling.
  • Cellular localization
    Cytoplasm. Membrane.
  • Information by UniProt

References

ab45560 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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