Overview

Description

  • Nature
    Synthetic
  • Amino Acid Sequence
    • Species
      Human
    • Sequence
      LVRALLQREA SKRPSARVAA N
    • Amino acids
      484 to 504

Associated products

Specifications

Our Abpromise guarantee covers the use of ab30903 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-PINK1 antibody (ab23707)

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: 0.02% Sodium Azide
    Constituents: 0.1% BSA, 200ul Tris buffered saline. pH 7.4

General Info

  • Alternative names
    • BRPK
    • FLJ27236
    • mitochondrial
    • PARK 6
    • PARK6
    • Phosphatase and Tensin Homolog
    • PINK 1
    • PINK1
    • PINK1_HUMAN
    • Protein kinase BRPK
    • PTEN induced putative kinase 1
    • PTEN induced putative kinase protein 1
    • PTEN-induced putative kinase protein 1
    • Serine/threonine kinase PINK1 mitochondrial
    • Serine/threonine protein kinase PINK1 mitochondrial
    • Serine/threonine-protein kinase PINK1
    see all
  • Function
    Protects against mitochondrial dysfunction during cellular stress, potentially by phosphorylating mitochondrial proteins. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy). It is necessary for PARK2 recruitement to dysfunctional mitochondria to initiate their degradation.
  • Tissue specificity
    Highly expressed in heart, skeletal muscle and testis, and at lower levels in brain, placenta, liver, kidney, pancreas, prostate, ovary and small intestine. Present in the embryonic testis from an early stage of development.
  • Involvement in disease
    Defects in PINK1 are the cause of Parkinson disease type 6 (PARK6) [MIM:605909]. A neurodegenerative disorder characterized by parkinsonian signs such as rigidity, resting tremor and bradykinesia. A subset of patients manifest additional symptoms including hyperreflexia, autonomic instability, dementia and psychiatric disturbances. Symptoms show diurnal fluctuation and can improve after sleep.
  • Sequence similarities
    Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
    Contains 1 protein kinase domain.
  • Post-translational
    modifications
    Autophosphorylated.
  • Cellular localization
    Mitochondrion outer membrane. Cytoplasm > cytosol.
  • Information by UniProt

References for Human PINK1 peptide (ab30903)

ab30903 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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