Overview

Description

  • Nature
    Synthetic
  • Amino Acid Sequence
    • Species
      Human
    • Sequence
      SMLAERRRKQKWAV-C
    • Amino acids
      2 to 15

Associated products

Specifications

Our Abpromise guarantee covers the use of ab22903 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-PINX1 antibody (ab2344)

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

General Info

  • Alternative names
    • 67-11-3 protein
    • FLJ20565
    • Hepatocellular carcinoma-related putative tumor suppressor
    • Liver-related putative tumor suppressor
    • LPTL
    • LPTS
    • MGC8850
    • OTTHUMP00000224984
    • OTTHUMP00000224985
    • OTTHUMP00000224986
    • OTTHUMP00000225053
    • OTTHUMP00000225054
    • PIN2 interacting protein 1
    • Pin2-interacting protein X1
    • PIN2/TERF1-interacting telomerase inhibitor 1
    • PINX1
    • PINX1_HUMAN
    • Protein 67-11-3
    • TRF1-interacting protein 1
    see all
  • Function
    Microtubule-binding protein essential for faithful chromosome segregation. Mediates TRF1 and TERT accumulation in nucleolus and enhances TRF1 binding to telomeres. Inhibits telomerase activity. May inhibit cell proliferation and act as tumor suppressor.
  • Tissue specificity
    Ubiquitous; expressed at low levels. Not detectable in a number of hepatocarcinoma cell lines.
  • Sequence similarities
    Belongs to the PINX1 family.
    Contains 1 G-patch domain.
  • Domain
    The TID (telomerase inhibiting domain) domain is sufficient to bind TERT and inhibit its activity.
    The TBM domain mediates interaction with TERF1.
  • Cellular localization
    Nucleus. Nucleus > nucleolus. Chromosome > telomere. Chromosome > centromere > kinetochore. Localizes in nucleoli, at telomere speckles and to the outer plate of kinetochores. Localization to the kinetochore is mediated by its central region and depends on NDC80 and CENPE.
  • Information by UniProt

References

ab22903 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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