Overview

Description

  • NatureSynthetic
  • Amino Acid Sequence
    • SpeciesHuman
    • SequenceSMLAERRRKQKWAV-C
    • Amino acids2 to 15

Associated products

Specifications

Our Abpromise guarantee covers the use of ab22903 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-PINX1 antibody (ab2344)

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

General Info

  • Alternative names
    • 67-11-3 protein
    • FLJ20565
    • Hepatocellular carcinoma-related putative tumor suppressor
    • Liver-related putative tumor suppressor
    • LPTL
    • LPTS
    • MGC8850
    • OTTHUMP00000224984
    • OTTHUMP00000224985
    • OTTHUMP00000224986
    • OTTHUMP00000225053
    • OTTHUMP00000225054
    • PIN2 interacting protein 1
    • Pin2-interacting protein X1
    • PIN2/TERF1-interacting telomerase inhibitor 1
    • PINX1
    • PINX1_HUMAN
    • Protein 67-11-3
    • TRF1-interacting protein 1
    see all
  • FunctionMicrotubule-binding protein essential for faithful chromosome segregation. Mediates TRF1 and TERT accumulation in nucleolus and enhances TRF1 binding to telomeres. Inhibits telomerase activity. May inhibit cell proliferation and act as tumor suppressor.
  • Tissue specificityUbiquitous; expressed at low levels. Not detectable in a number of hepatocarcinoma cell lines.
  • Sequence similaritiesBelongs to the PINX1 family.
    Contains 1 G-patch domain.
  • DomainThe TID (telomerase inhibiting domain) domain is sufficient to bind TERT and inhibit its activity.
    The TBM domain mediates interaction with TERF1.
  • Cellular localizationNucleus. Nucleus > nucleolus. Chromosome > telomere. Chromosome > centromere > kinetochore. Localizes in nucleoli, at telomere speckles and to the outer plate of kinetochores. Localization to the kinetochore is mediated by its central region and depends on NDC80 and CENPE.
  • Information by UniProt

References for Human PINX1 peptide (ab22903)

ab22903 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"