Function: Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm.
Tissue specificity: Detected in fetal brain, lung, liver and kidney.
Similarity: Belongs to the plexin family.
Contains 4 IPT/TIG domains.
Contains 1 Sema domain.
Immunocytochemical double labelling using anti-Myc mouse monoclonal anti-Plexin A1 rabbit polyclonal antibodies in Cos-7 cells mock transfected (A,D) or transfected with Myc-tagged mouse Plexin A1 construct (B,E). The specificity of the binding protein in E was demonstrated using Plexin A1 peptide (ab42757 at 1µg/ml) in the presence of this Plexin A1 antibody (C,F).
has not yet been referenced specifically in any publications.
Publishing research using ab42757? Please let us know so that we can cite the reference in this datasheet.
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