Overview

Description

  • Nature
    Synthetic

Specifications

Our Abpromise guarantee covers the use of ab73685 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Purity
    70 - 90% by HPLC.

  • Form
    Liquid
  • Additional notes

    - First try to dissolve a small amount of peptide in either water or buffer. The more charged residues on a peptide, the more soluble it is in aqueous solutions.
    - If the peptide doesn’t dissolve try an organic solvent e.g. DMSO, then dilute using water or buffer.
    - Consider that any solvent used must be compatible with your assay. If a peptide does not dissolve and you need to recover it, lyophilise to remove the solvent.
    - Gentle warming and sonication can effectively aid peptide solubilisation. If the solution is cloudy or has gelled the peptide may be in suspension rather than solubilised.
    - Peptides containing cysteine are easily oxidised, so should be prepared in solution just prior to use.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Information available upon request.

General Info

  • Alternative names
    • ANM8_HUMAN
    • Heterogeneous nuclear ribonucleoprotein methyltransferase like protein 4
    • Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 4
    • HMT1 hnRNP methyltransferase like 3
    • HMT1 hnRNP methyltransferase like 4
    • HRMT1 L3
    • HRMT1 L4
    • HRMT1L 3
    • HRMT1L 4
    • HRMT1L3
    • HRMT1L4
    • prmt8
    • Protein arginine N methyltransferase 4
    • Protein arginine N methyltransferase 8
    • Protein arginine N-methyltransferase 8
    see all
  • Function
    Membrane-associated arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA). Able to mono- and dimethylate EWS protein; however its precise role toward EWS remains unclear as it still interacts with fully methylated EWS.
  • Tissue specificity
    Brain-specific.
  • Sequence similarities
    Belongs to the protein arginine N-methyltransferase family. PRMT8 subfamily.
  • Domain
    The SH3-binding motifs mediate the interaction with SH3 domain-containing proteins such as PRMT2 and FYN, possibly leading to displace the N-terminal domain and activate the protein.
    The N-terminal region (1-60) inhibits the enzymatic activity.
  • Cellular localization
    Cell membrane.
  • Information by UniProt

References

ab73685 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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