Overview

Description

  • NatureSynthetic
  • Amino Acid Sequence
    • AccessionP25786
    • SpeciesHuman
    • SequencePADEPAEKADEPMEH
    • Amino acids249 to 263

Associated products

Specifications

Our Abpromise guarantee covers the use of ab4943 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking

  • FormLiquid
  • Additional notes


    This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and human proteasome 20S C2 subunit, catalog ab3325. Using a solution of peptide of equal volume and concentration to the corresponding antibody will yield a large molar excess of peptide (~ 70-fold) for competitive inhibition of antibody-protein binding reactions.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

General Info

  • Alternative names
    • 30 kDa prosomal protein
    • HC 2
    • HC2
    • Macropain subunit C2
    • Macropain subunit nu
    • MGC14542
    • MGC14575
    • MGC14751
    • MGC1667
    • MGC21459
    • MGC22853
    • MGC23915
    • Multicatalytic endopeptidase complex subunit C2
    • NU
    • PROS 30
    • PROS-30
    • PROS30
    • Proteasome (prosome macropain) subunit alpha type 1
    • Proteasome alpha 1 subunit
    • Proteasome component C2
    • Proteasome nu chain
    • Proteasome subunit alpha type 1
    • Proteasome subunit alpha type I
    • Proteasome subunit alpha type-1
    • Proteasome subunit nu
    • Protein P30 33K
    • PSA1_HUMAN
    • PSC 2
    • PSC2
    • PSMA 1
    • psmA1
    see all
  • FunctionThe proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Mediates the lipopolysaccharide-induced signal transduction in the macrophage proteasome (By similarity). Might be involved in the anti-inflammatory response of macrophages during the interaction with C.albicans heat-inactivated cells.
  • Sequence similaritiesBelongs to the peptidase T1A family.
  • Cellular localizationCytoplasm. Nucleus.
  • Information by UniProt

References for Human Proteasome 20S C2 peptide (ab4943)

This product has been referenced in:
  • Chu Y  et al. Alterations in lysosomal and proteasomal markers in Parkinson's disease: relationship to alpha-synuclein inclusions. Neurobiol Dis 35:385-98 (2009). Read more (PubMed: 19505575) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"