Overview

Description

  • NatureSynthetic
  • Amino Acid Sequence
    • AccessionP28062
    • SpeciesHuman
    • SequenceVESTDVSDLLHQYREA
    • Amino acids259 to 274

Associated products

Specifications

Our Abpromise guarantee covers the use of ab4945 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking

  • FormLiquid
  • Additional notes


    This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and human proteasome 20S LMP7, catalog ab3329. Using a solution of peptide of equal volume and concentration to the corresponding antibody will yield a large molar excess of peptide (~ 70-fold) for competitive inhibition of antibody-protein binding reactions.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

General Info

  • Alternative names
    • ALDD
    • D6S216
    • D6S216E
    • Large multifunctional peptidase 7
    • Large multifunctional protease 7
    • LMP 7
    • LMP7
    • Low molecular mass protein 7
    • Low molecular weight protein 7
    • Macropain subunit C13
    • MGC1491
    • Multicatalytic endopeptidase complex subunit C13
    • NKJO
    • OTTHUMP00000062981
    • Protease component C13
    • Proteasome (prosome macropain) subunit beta type 8
    • Proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)
    • Proteasome beta 8 subunit
    • Proteasome catalytic subunit 3i
    • Proteasome component C13
    • Proteasome related gene 7
    • Proteasome subunit beta 5i
    • Proteasome subunit beta 8
    • Proteasome subunit beta type
    • Proteasome subunit beta type 8
    • Proteasome subunit beta type-8
    • Proteasome subunit beta-5i
    • Proteasome subunit Y2
    • PSB8_HUMAN
    • PSMB 8
    • PSMB5i
    • PSMB8
    • Really interesting new gene 10 protein
    • RING 10
    • RING10
    • Y2
    see all
  • FunctionThe proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. Replacement of PSMB5 by PSMB8 increases the capacity of the immunoproteasome to cleave model peptides after hydrophobic and basic residues. Acts as a major component of interferon gamma-induced sensitivity. Plays a key role in apoptosis via the degradation of the apoptotic inhibitor MCL1. May be involved in the inflammatory response pathway. In cancer cells, substitution of isoform 1 (E2) by isoform 2 (E1) results in immunoproteasome deficiency.
  • Involvement in diseaseDefects in PSMB8 are the cause of JMP syndrome (JMPS) [MIM:613732]; also called joint contractures muscular atrophy microcytic anemia and panniculitis-induced lipodystrophy. JBTS1 is an autoinflammatory disorder characterized by childhood onset of joint stiffness and severe contractures of the hands and feet, erythematous skin lesions with subsequent development of severe lipodystrophy, and laboratory evidence of immune dysregulation. Accompanying features include muscle weakness and atrophy, hepatosplenomegaly, and microcytic anemia.
  • Sequence similaritiesBelongs to the peptidase T1B family.
  • Developmental stageHighly expressed in immature dendritic cells (at protein level).
  • Post-translational
    modifications
    Autocleaved. The resulting N-terminal Thr residue of the mature subunit is responsible for the nucleophile proteolytic activity.
  • Cellular localizationCytoplasm. Nucleus.
  • Information by UniProt

References for Human Proteasome 20S LMP7 peptide (ab4945)

ab4945 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"