Overview

Description

  • Nature
    Synthetic
  • Amino Acid Sequence
    • Species
      Human
    • Sequence
      C-LKVKGEKSGLMST
    • Amino acids
      487 to 499

Associated products

Specifications

Our Abpromise guarantee covers the use of ab22909 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-PRPF31 antibody (ab2467)

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

General Info

  • Alternative names
    • DKFZp566J153
    • hPrp 31
    • hPrp31
    • NY BR 99
    • Pre mRNA processing factor 31
    • Pre mRNA processing factor 31 homolog
    • Pre mRNA processing factor 31 homolog (yeast)
    • Pre-mRNA-processing factor 31
    • Precursor mRNA-processing factor 31, S. cerevisiae, homolog of
    • Protein 61K
    • PRP 31
    • PRP31
    • PRP31 pre mRNA processing factor 31 homolog
    • PRP31 pre mRNA processing factor 31 homolog (yeast)
    • PRP31_HUMAN
    • PRPF 31
    • prpf31
    • RP 11
    • RP11
    • Serologically defined breast cancer antigen NY BR 99
    • Serologically defined breast cancer antigen NY-BR-99
    • SNRNP61
    • U4/U6 small nuclear ribonucleoprotein Prp31
    • U4/U6 snRNP 61 kDa protein
    see all
  • Function
    Involved in pre-mRNA splicing. Required for U4/U6.U5 tri-snRNP formation.
  • Tissue specificity
    Ubiquitously expressed.
  • Involvement in disease
    Defects in PRPF31 are the cause of retinitis pigmentosa type 11 (RP11) [MIM:600138]. RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. RP11 inheritance is autosomal dominant.
  • Sequence similarities
    Belongs to the PRP31 family.
    Contains 1 Nop domain.
  • Domain
    Interacts with the snRNP via the Nop domain.
    The coiled coil domain is formed by two non-contiguous helices.
  • Cellular localization
    Nucleus speckle. Nucleus > Cajal body. Predominantly found in speckles and in Cajal bodies.
  • Information by UniProt

References for Human PRPF31 peptide (ab22909)

ab22909 has not yet been referenced specifically in any publications.

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