Human PTHLH peptide (ab42283)
Key features and details
- Purity: > 95% HPLC
- Suitable for: Blocking
Description
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Product name
Human PTHLH peptide
See all PTHLH proteins and peptides -
Purity
> 95 % HPLC. -
Animal free
No -
Nature
Synthetic -
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Species
Human -
Sequence
TRSAW -
Amino acids
107 to 111
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Specifications
Our Abpromise guarantee covers the use of ab42283 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Applications
Blocking
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Form
Lyophilized -
Concentration information loading...
Preparation and Storage
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Stability and Storage
Shipped at 4°C. After reconstitution store at -20ºC. Avoid freeze / thaw cycles.
Constituent: 0.1% Acetic acid
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ReconstitutionStore at 2 to -8°C lyophilised, resuspend in 0.1% actetic acid
General Info
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Alternative names
- HHM
- MGC14611
- Osteostatin
see all -
Function
Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. Required for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs. Upregulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of these cells to BMPs and allows them to respond to BMP4 in a paracrine and/or autocrine fashion. BMP4 signaling in the mesenchyme, in turn, triggers epithelial outgrowth and augments MSX2 expression, which causes the mammary mesenchyme to inhibit hair follicle formation within the nipple sheath (By similarity). Promotes colon cancer cell migration and invasion in an integrin alpha-6/beta-1-dependent manner through activation of Rac1.
Osteostatin is a potent inhibitor of osteoclastic bone resorption. -
Tissue specificity
Ubiquitous. Also expressed in the mammary gland. -
Involvement in disease
Brachydactyly E2 -
Sequence similarities
Belongs to the parathyroid hormone family. -
Post-translational
modificationsThere are 3 principal secretory forms, called PTHrP[1-36], PTHrP[38-94], and osteostatin (PTHrP[107-139]) arising from endoproteolytic cleavage of the initial translation product. Each of these secretory forms is believed to have one or more of its own receptors that mediates the normal paracrine, autocrine and endocrine actions. -
Cellular localization
Cytoplasm. Nucleus. Secreted. - Information by UniProt
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
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Datasheet download
References (0)
ab42283 has not yet been referenced specifically in any publications.