The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Blocking - Blocking peptide for Anti-RAC2 antibody (ab2244)
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
p21 Rac 2
Ras related C3 botulinum toxin substrate 2
Ras related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2
Ras related C3 botulinum toxin substrate 3
Ras related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac2)
Ras-related C3 botulinum toxin substrate 2
Rho family small GTP binding protein Rac 2
Rho family small GTP binding protein Rac2
Small G protein
FunctionPlasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as secretory processes, phagocytose of apoptotic cells and epithelial cell polarization. Augments the production of reactive oxygen species (ROS) by NADPH oxidase.
Tissue specificityHematopoietic specific.
Involvement in diseaseDefects in RAC2 are the cause of neutrophil immunodeficiency syndrome (NEUID) [MIM:608203].
Sequence similaritiesBelongs to the small GTPase superfamily. Rho family.
Cellular localizationCytoplasm. Membrane-associated when activated.