Overview

Description

  • Nature
    Synthetic
  • Amino Acid Sequence
    • Species
      Human
    • Sequence
      CAGDRLTGIPSHILNSSPSD Amino acids 99 to 117 of human RAIDD (1,2)
    • Amino acids
      99 to 117

Specifications

Our Abpromise guarantee covers the use of ab8460 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking

    Western blot

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    PBS with 0.1% BSA 0.02% sodium azide pH7.2

General Info

  • Alternative names
    • CASP2 and RIPK1 domain containing adaptor with death domain
    • Caspase and RIP adapter with death domain
    • Caspase and RIP adaptor with death domain
    • Cradd
    • CRADD_HUMAN
    • Death adaptor molecule RAIDD
    • Death domain containing protein CRADD
    • Death domain-containing protein CRADD
    • MGC9163
    • RIP associated ICH1/CED3 homologous protein with death domain
    • RIP associated protein with a death domain
    • RIP-associated protein with a death domain
    see all
  • Function
    Apoptotic adaptor molecule specific for caspase-2 and FASL/TNF receptor-interacting protein RIP. In the presence of RIP and TRADD, CRADD recruits caspase-2 to the TNFR-1 signalling complex.
  • Tissue specificity
    Constitutively expressed in most tissues, with particularly high expression in adult heart, testis, liver, skeletal muscle, fetal liver and kidney.
  • Sequence similarities
    Contains 1 CARD domain.
    Contains 1 death domain.
  • Domain
    Contains a death domain involved in the binding of RIP protein.
    The CARD domain mediates the interaction with caspase-2.
  • Information by UniProt

References

ab8460 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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