Overview

Description

  • NatureSynthetic
  • Amino Acid Sequence
    • SpeciesHuman
    • SequenceC-NSAQRRLGDSSDL
    • Amino acids158 to 170

Specifications

Our Abpromise guarantee covers the use of ab23004 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

General Info

  • Alternative names
    • GRP4_HUMAN
    • Guanyl nucleotide releasing protein 4
    • RAS guanyl releasing protein 4
    • RAS guanyl-releasing protein 4
    • RASGRP4
    see all
  • FunctionFunctions as a cation- and diacylglycerol (DAG)-regulated nucleotide exchange factor activating Ras through the exchange of bound GDP for GTP. May function in mast cells differentiation.
  • Tissue specificityExpressed by mast cells and their progenitors (at protein level). Specifically expressed in mononuclear leukocytes. Highly expressed in myeloid cells compared to lymphoid cells. Also detected in heart, skeletal muscle, spleen, liver, placenta and lung. Not detected in brain. Isoform 1 is the major isoform in normal individuals. Isoform 2 is more significantly expressed in a patient with asthma. Isoform 3 is more significantly expressed in a patient with asthma and a mastocytosis patient.
  • Sequence similaritiesBelongs to the RASGRP family.
    Contains 1 EF-hand domain.
    Contains 1 N-terminal Ras-GEF domain.
    Contains 1 phorbol-ester/DAG-type zinc finger.
    Contains 1 Ras-GEF domain.
  • Developmental stageExpressed early during development. Detected in all fetal tissues tested.
  • DomainThe phorbol-ester/DAG-type zinc finger mediates the binding and the functional activation by DAG.
  • Cellular localizationCytoplasm. Cell membrane. Recruited to membranes upon activation by DAG.
  • Information by UniProt

References for Human RASGRP 4 peptide (ab23004)

ab23004 has not yet been referenced specifically in any publications.

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