Human RBM10 protein fragment (ab91978)
- Product nameHuman RBM10 protein fragment
- SourceE. coli
- Amino Acid Sequence
- SequenceGSKRDMASNEGSRISAASVASTAIAAAQWAISQASQGGEG TWATSEEPPVDYSY YQQDEGYGNSQGTESSLYAHGYLK GTKGPGITGTKGDPTGAGPEASLEPGADSV SMQAFSRA QPGAAPGIYQQSAEASSSQGTAANSQSYTIMSPAVLKSEL QSPTHP SSALPPATSPTAQESYSQYPVPDVSTYQYDET SGYYYDPQTGLYYDPNSQYYYN AQSQQYLYWDGERRTY VPALEQSADGHKETGAPSKEGKEKKEKHKTKTAQQIAK DMERWARSLNKQKENFKNSFQPISSLRDDERRESATADAG YAILEKKGALAERQ HTSMDLPKLASDDRPSPPRGLVAA YSGESDSEEEQERGGPEREEKLTDWQKLAC LLCRRQFP SKEALIRHQQLSGLHKQNLEIHRRAHLSENELEALEKNDM EQMKYR DRAAERREKYGIPEPPEPKRRKYGGISTASVD FEQPTRDGLGSDNIGSRMLQAM GWKEGSGLGRKKQGIV TPIEAQTRVRGSGLGARGSSYGVTSTESYKETLHKTMV TRFNEAQ
- Amino acids306 to 852
Our Abpromise guarantee covers the use of ab91978 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
- Concentration information loading...
Preparation and Storage
- Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
Constituents: 0.5% Trehalose, 6M Urea, 100mM Sodium phosphate, 10mM Sodium chloride, pH 4.5
- ReconstitutionReconstitute with 105 µl aqua dest.
- G patch domain containing protein 9
- G patch domain-containing protein 9
- RNA binding motif protein 10
- RNA binding protein 10
- RNA binding protein S1-1
- RNA-binding motif protein 10
- RNA-binding protein 10
- RNA-binding protein S1-1
- FunctionMay be involved in post-transcriptional processing, most probably in mRNA splicing. Binds to RNA homopolymers, with a preference for poly(G) and poly(U) and little for poly(A).
- Involvement in diseaseDefects in RBM10 are the cause of TARP syndrome (TARPS) [MIM:311900]. It is a disorder characterized by the Robin sequence (micrognathia, glossoptosis and cleft palate), talipes equinovarus and cardiac defects.
- Sequence similaritiesContains 1 C2H2-type zinc finger.
Contains 1 G-patch domain.
Contains 1 RanBP2-type zinc finger.
Contains 2 RRM (RNA recognition motif) domains.
modificationsPhosphorylated upon DNA damage, probably by ATM or ATR.
- Cellular localizationNucleus. In the extranucleolar nucleoplasm constitutes hundreds of nuclear domains, which dynamically change their structures in a reversible manner. Upon globally reducing RNA polymerase II transcription, the nuclear bodies enlarge and decrease in number. They occur closely adjacent to nuclear speckles or IGCs (interchromatin granule clusters) but coincide with TIDRs.
Human RBM10 protein fragment images
The image shows an electrophoretic assay performed using an Agilent 5100 ALP. In some images colored control bands can be seen at 15 kDa (green) and/or 240 kDa (purple). The protein-specific band is blue.
References for Human RBM10 protein fragment (ab91978)
ab91978 has not yet been referenced specifically in any publications.