Overview

  • Product nameHuman RBPJK peptide

Description

  • NatureSynthetic

Specifications

Our Abpromise guarantee covers the use of ab26983 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • FormLiquid
  • Additional notes

    - First try to dissolve a small amount of peptide in either water or buffer. The more charged residues on a peptide, the more soluble it is in aqueous solutions.
    - If the peptide doesn’t dissolve try an organic solvent e.g. DMSO, then dilute using water or buffer.
    - Consider that any solvent used must be compatible with your assay. If a peptide does not dissolve and you need to recover it, lyophilise to remove the solvent.
    - Gentle warming and sonication can effectively aid peptide solubilisation. If the solution is cloudy or has gelled the peptide may be in suspension rather than solubilised.
    - Peptides containing cysteine are easily oxidised, so should be prepared in solution just prior to use.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Information available upon request.

General Info

  • Alternative names
    • AI843960
    • CBF 1
    • CBF-1
    • CBF1
    • IGKJRB1
    • J kappa recombination signal binding protein
    • J kappa-recombination signal-binding protein
    • KBF2
    • NY REN 30 antigen
    • RBP J kappa
    • RBP-J
    • RBP-J kappa
    • RBP-JK
    • Rbpj
    • RBPJK
    • RBPSUH
    • Recombining binding protein suppressor of hairless
    • Renal carcinoma antigen NY-REN-30
    • SUH_HUMAN
    see all
  • FunctionTranscriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some NICD product of Notch proteins (Notch intracellular domain), it acts as a transcriptional activator that activates transcription of Notch target genes. Probably represses or activates transcription via the recruitment of chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins, respectively. Specifically binds to the immunoglobulin kappa-type J segment recombination signal sequence.
  • Sequence similaritiesBelongs to the Su(H) family.
    Contains 1 IPT/TIG domain.
  • Cellular localizationNucleus. Cytoplasm. Mainly nuclear, upon interaction with RITA/C12orf52, translocates to the cytoplasm, down-regulating the Notch signaling pathway.
  • Information by UniProt

References for Human RBPJK peptide (ab26983)

ab26983 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab26983.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"