Overview

Description

  • NatureSynthetic
  • Amino Acid Sequence
    • SpeciesHuman
    • SequenceCRQPVLGSNIANNG
    • Amino acids672 to 685

Specifications

Our Abpromise guarantee covers the use of ab23003 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

General Info

  • Alternative names
    • E3 ubiquitin-protein ligase RNF6
    • Ring finger protein (C3H2C3 type) 6
    • Ring finger protein 6
    • RING H2 protein
    • RING H2 protein RNF6
    • RNF 6
    • RNF6
    • RNF6_HUMAN
    • SPG2
    see all
  • FunctionE3 ubiquitin-protein ligase mediating 'Lys-48'-linked polyubiquitination of LIMK1 and its subsequent targeting to the proteasome for degradation. Negatively regulates axonal outgrowth through regulation of the LIMK1 turnover. Mediates 'Lys-6' and 'Lys-27'-linked polyubiquitination of AR/androgen receptor thereby modulating its transcriptional activity. May also bind DNA and function as a transcriptional regulator.
  • Tissue specificityWeakly expressed in peripheral blood, spleen, prostate, testis and ovary. According to PubMed:18368307, it is preferentially expressed in testis and ovary and hardly detected in other tissues.
  • PathwayProtein modification; protein ubiquitination.
  • Involvement in diseaseDefects in RNF6 may be a cause of esophageal cancer (ESCR) [MIM:133239]. A malignancy of the esophagus. The most common types are esophageal squamous cell carcinoma and adenocarcinoma. Cancer of the esophagus remains a devastating disease because it is usually not detected until it has progressed to an advanced incurable stage.
  • Sequence similaritiesBelongs to the RNF12 family.
    Contains 1 RING-type zinc finger.
  • Developmental stageExpressed in embryo and adult testis.
  • Cellular localizationNucleus. Cytoplasm. Cell projection > axon. Nucleus > PML body. Localizes to the PML nuclear bodies in Sertoli cells.
  • Information by UniProt

References for Human RNF6 peptide (ab23003)

ab23003 has not yet been referenced specifically in any publications.

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