Overview

Description

  • NatureSynthetic
  • Amino Acid Sequence
    • SpeciesHuman
    • SequenceKELFTSEFEPAMQIDG
    • Amino acids541 to 556

Associated products

Specifications

Our Abpromise guarantee covers the use of ab39775 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-ROR alpha antibody (ab16367)

    Neutralising

  • Purity> 90 % SDS-PAGE.
    This antibody is greater than 70% pure.
  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Double distilled water or equivalent after reconstitution.

General Info

  • Alternative names
    • fhl2a
    • NR1F1
    • Nuclear receptor ROR-alpha
    • Nuclear receptor RZR-alpha
    • Nuclear receptor subfamily 1 group F member 1
    • RAR-related orphan receptor A
    • Retinoid-related orphan receptor-alpha
    • Rora
    • RORA_HUMAN
    • RZR-ALPHA
    • RZRA
    see all
  • FunctionOrphan nuclear receptor. Binds DNA as a monomer to hormone response elements (HRE) containing a single core motif half-site preceded by a short A-T-rich sequence. This isomer binds to the consensus sequence 5'-[AT][TA]A[AT][CGT]TAGGTCA-3'. Regulates a number of genes involved in lipid metabolism such as apolipoproteins AI, APOA5, CIII, CYP71 and PPARgamma, in cerebellum and photoreceptor development including PCP2, OPN1SW, OPN1SM AND ARR3, in circadian rhythm with BMAL1, and skeletal muscle development with MYOD1. Possible receptor for cholesterol or one of its derivatives.
  • Tissue specificityWidely expressed in a number of tissues.
  • Sequence similaritiesBelongs to the nuclear hormone receptor family. NR1 subfamily.
    Contains 1 nuclear receptor DNA-binding domain.
  • Post-translational
    modifications
    Phosphorylation by PKC in neurons inhibits transcriptional activity. Phosphorylated on Thr-216 by ERK2 in vitro.
    Sumoylated by SENP1 and SENP2. Sumoylation, promoted by PIAS2, PIAS3, PIASy but not PIAS1, enhances the transcriptional activity. Desumoylated by SENP1.
    Ubiquitinated. Ubiquitination is required for efficient transcriptional activity and is prevented by Hairless.
  • Cellular localizationNucleus.
  • Information by UniProt

References for Human ROR alpha peptide (ab39775)

ab39775 has not yet been referenced specifically in any publications.

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