Overview

Description

  • NatureRecombinant
  • SourceE. coli
  • Amino Acid Sequence
    • SpeciesHuman
    • SequenceYCTGLLLARRLLNRFGMDKIYEGQVEVTGDEYNVESIDGQPGAFTCYLDA GLA RTTTGNKVFGALKGAVDGGLSIPHSTKRFPGYDSESKEFNAEVHR KHIMGQNV ADYMRYLMEEDEDAYKKQFSQYIKNSVTPDMMEEMYKKAH AAIRENPVYEKKP KKEVKKKRWNRPKMSLAQKKDRVAQKKASFLRAQE RAAES
    • Amino acids99 to 297

Specifications

Our Abpromise guarantee covers the use of ab91956 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • FormLyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 0.5% Trehalose, 6M Urea, 100mM Sodium phosphate, 10mM Sodium chloride, pH 4.5

  • ReconstitutionReconstitute with 46 µl distilled water.

General info

  • Alternative names
    • 60S ribosomal protein L5
    • DBA6
    • L5
    • MSTP030
    • Ribosomal protein L5
    • RL5
    • RL5_HUMAN
    • RP L5
    • RPL 5
    • RPL5
    • U21 RNA
    • U21RNA
    see all
  • FunctionRequired for rRNA maturation and formation of the 60S ribosomal subunits. This protein binds 5S RNA.
  • Involvement in diseaseDefects in RPL5 are the cause of Diamond-Blackfan anemia type 6 (DBA6) [MIM:612561]. DBA6 is a form of Diamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy. Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of malignancy. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenital anomalies, the most frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenital anomalies.
  • Sequence similaritiesBelongs to the ribosomal protein L18P family.
  • Cellular localizationCytoplasm. Nucleus > nucleolus.
  • Information by UniProt

Human RPL5 protein fragment images

  • The image shows an electrophoretic assay performed using an Agilent 5100 ALP. In some images coloured control bands can be seen at 15 kDa (green) and/or 240 kDa (purple). The protein-specific band is blue.

References for Human RPL5 protein fragment (ab91956)

ab91956 has not yet been referenced specifically in any publications.

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