Overview

Description

  • Nature
    Synthetic
  • Amino Acid Sequence
    • Species
      Human
    • Sequence
      MKGNGIVECLGPK
    • Amino acids
      3374 to 346

Associated products

Specifications

Our Abpromise guarantee covers the use of ab23106 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-SAE1 antibody (ab5645)

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

General Info

  • Alternative names
    • Activator of SUMO1
    • AOS1
    • HSPC140
    • Sae1
    • SAE1_HUMAN
    • Sentrin/SUMO activating protein AOS1
    • SUA1
    • SUMO 1 activating enzyme E1 N subunit
    • SUMO 1 activating enzyme subunit 1
    • SUMO-activating enzyme subunit 1
    • Ubiquitin like protein SUMO1 activating enzyme
    • Ubiquitin-like 1-activating enzyme E1A
    • UBL E1A
    • UBLE1A
    see all
  • Function
    The heterodimer acts as a E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2.
  • Tissue specificity
    Expression level increases during S phase and drops in G2 phase (at protein level).
  • Pathway
    Protein modification; protein sumoylation.
  • Sequence similarities
    Belongs to the ubiquitin-activating E1 family.
  • Post-translational
    modifications
    Phosphorylated upon DNA damage, probably by ATM or ATR.
  • Cellular localization
    Nucleus.
  • Information by UniProt

References for Human SAE1 peptide (ab23106)

ab23106 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab23106.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

Sign up