Hematopoietic adaptor containing SH3 and SAM domains 1
Nuclear localization signals SAM and SH3 domain containing 1
SAM and SH3 domain containing 2
SAM domain containing protein SAMSN 1
SAM domain SH3 domain and nuclear localisation signals 1
SAM domain SH3 domain and nuclear localization signals 1
SAM domain, SH3 domain and nuclear localization signals protein 1
SAM domain-containing protein SAMSN-1
SH3 domain and nuclear localisation signals 1
SH3 domain and nuclear localization signals protein 1
SH3 SAM adaptor protein
SH3-SAM adaptor protein
Src homology domain 3 (SH3) containing adapter protein SH3 lymphocyte protein 2
FunctionNegative regulator of B-cell activation. Down-regulates cell proliferation (in vitro). Promotes RAC1-dependent membrane ruffle formation and reorganization of the actin cytoskeleton. Regulates cell spreading and cell polarization. Stimulates HDAC1 activity. Regulates LYN activity by modulating its tyrosine phosphorylation.
Tissue specificityDetected in peripheral blood B-cells (at protein level). Detected in spleen, liver and peripheral blood.