Overview

Description

  • Nature
    Synthetic
  • Amino Acid Sequence
    • Species
      Human
    • Sequence
      IRLDTLSASLGRS-C

Associated products

Specifications

Our Abpromise guarantee covers the use of ab45611 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-SAMSN1 antibody (ab21206)

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

General Info

  • Alternative names
    • HACS1
    • Hematopoietic adapter containing SH3 and sterile α motif (SAM) domains 1
    • Hematopoietic adapter containing SH3 and sterile alpha motif (SAM) domains 1
    • Hematopoietic adaptor containing SH3 and SAM domains 1
    • Nash1
    • Nuclear localization signals SAM and SH3 domain containing 1
    • SAM and SH3 domain containing 2
    • SAM domain
    • SAM domain containing protein SAMSN 1
    • SAM domain SH3 domain and nuclear localisation signals 1
    • SAM domain SH3 domain and nuclear localization signals 1
    • SAM domain, SH3 domain and nuclear localization signals protein 1
    • SAM domain-containing protein SAMSN-1
    • SAMN1_HUMAN
    • SAMSN 1
    • Samsn1
    • SASH2
    • SH3 domain and nuclear localisation signals 1
    • SH3 domain and nuclear localization signals protein 1
    • SH3 SAM adaptor protein
    • SH3-SAM adaptor protein
    • SH3D6B
    • SLy2
    • Src homology domain 3 (SH3) containing adapter protein SH3 lymphocyte protein 2
    see all
  • Function
    Negative regulator of B-cell activation. Down-regulates cell proliferation (in vitro). Promotes RAC1-dependent membrane ruffle formation and reorganization of the actin cytoskeleton. Regulates cell spreading and cell polarization. Stimulates HDAC1 activity. Regulates LYN activity by modulating its tyrosine phosphorylation.
  • Tissue specificity
    Detected in peripheral blood B-cells (at protein level). Detected in spleen, liver and peripheral blood.
  • Sequence similarities
    Contains 1 SAM (sterile alpha motif) domain.
    Contains 1 SH3 domain.
  • Cellular localization
    Nucleus. Cytoplasm. Cell projection > ruffle. Shuttles between cytoplasm and nucleus. Colocalizes with the actin cytoskeleton and actin-rich membrane ruffles.
  • Information by UniProt

References

ab45611 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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