Overview

  • Product nameHuman SARM peptide

Description

  • NatureSynthetic
  • Amino Acid Sequence
    • SpeciesHuman

Associated products

Specifications

Our Abpromise guarantee covers the use of ab41853 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-SARM antibody (ab17812)

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: 0.02% Sodium Azide
    Constituents: 0.1% BSA, PBS (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl), pH 7.2

General Info

  • Alternative names
    • FLJ36296
    • KIAA0524
    • MyD88-5
    • SAM and ARM-containing protein
    • SAM domain-containing protein 2
    • SAMD2
    • SARM 1
    • SARM1
    • SARM1_HUMAN
    • Sterile alpha and Armadillo repeat protein
    • sterile alpha and HEAT/Armadillo motif protein, ortholog of Drosophila
    • sterile alpha and HEAT/Armadillo motifs-containing protein
    • sterile alpha and TIR motif containing 1
    • Sterile alpha and TIR motif-containing protein 1
    • Sterile alpha and TIR motifs-containing protein 1
    • Sterile alpha motif domain-containing protein 2
    • Tir-1 homolog
    see all
  • FunctionInvolved in innate immnune response. Acts as a negative regulator of TICAM1/TRIF-dependent Toll-like receptor signaling by inhibiting induction of TLR3- and TLR4-dependent genes. Specifically blocks TICAM1/TRIF-dependent transcription-factor activation and gene induction, without affecting the MYD88-dependent pathway or non-TLR signaling. Negative regulator of NF-kappa-B and IRF activation.
  • Tissue specificityPredominantly expressed in kidney and liver. Expressed at lower level in placenta.
  • Sequence similaritiesContains 2 SAM (sterile alpha motif) domains.
    Contains 1 TIR domain.
  • Cellular localizationCytoplasm.
  • Information by UniProt

References for Human SARM peptide (ab41853)

ab41853 has not yet been referenced specifically in any publications.

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