The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Blocking - Blocking peptide for Anti-SARM antibody (ab17812)
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Preservative: 0.02% Sodium Azide
Constituents: 0.1% BSA, PBS (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl), pH 7.2
SAM and ARM-containing protein
SAM domain-containing protein 2
Sterile alpha and Armadillo repeat protein
sterile alpha and HEAT/Armadillo motif protein, ortholog of Drosophila
sterile alpha and HEAT/Armadillo motifs-containing protein
sterile alpha and TIR motif containing 1
Sterile alpha and TIR motif-containing protein 1
Sterile alpha and TIR motifs-containing protein 1
Sterile alpha motif domain-containing protein 2
FunctionInvolved in innate immnune response. Acts as a negative regulator of TICAM1/TRIF-dependent Toll-like receptor signaling by inhibiting induction of TLR3- and TLR4-dependent genes. Specifically blocks TICAM1/TRIF-dependent transcription-factor activation and gene induction, without affecting the MYD88-dependent pathway or non-TLR signaling. Negative regulator of NF-kappa-B and IRF activation.
Tissue specificityPredominantly expressed in kidney and liver. Expressed at lower level in placenta.
Sequence similaritiesContains 2 SAM (sterile alpha motif) domains. Contains 1 TIR domain.