Overview

Description

  • NatureSynthetic
  • Amino Acid Sequence
    • SpeciesHuman
    • SequenceMSNADFAKLFLRK
    • Amino acids951 to 963

Associated products

Specifications

Our Abpromise guarantee covers the use of ab45492 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-SART3 antibody (ab36137)

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.

General Info

  • Alternative names
    • DSAP1
    • hSART 3
    • hSART-3
    • P100
    • P110
    • p110(nrb)
    • RP11 13G14
    • SART 3
    • SART-3
    • SART3
    • SART3_HUMAN
    • Squamous cell carcinoma antigen recognized by T cells 3
    • Squamous cell carcinoma antigen recognized by T-cells 3
    • Tat interacting protein of 110 kDa
    • Tat-interacting protein of 110 kDa
    • Tip110
    see all
  • FunctionRegulates Tat transactivation activity through direct interaction. May be a cellular factor for HIV-1 gene expression and viral replication.
  • Tissue specificityUbiquitously expressed.
  • Involvement in diseaseDefects in SART3 are the cause of disseminated superficial actinic porokeratosis type 1 (DSAP1) [MIM:175900]. DSAP1 is an autosomal dominant disorder, characterized by multiple superficial keratotic lesions surrounded by a slightly raised keratotic border, developing during the third or fourth decade of life on sun-exposed areas of skin.
  • Sequence similaritiesContains 8 HAT repeats.
    Contains 2 RRM (RNA recognition motif) domains.
  • Post-translational
    modifications
    Phosphorylated upon DNA damage, probably by ATM or ATR.
  • Cellular localizationCytoplasm. Nucleus speckle. Localized in speckles. Expressed in the nucleus of all of the malignant tumor cell lines tested and the majority of cancer tissues with various histologies, including squamous cell carcinomas (SCC), adenocarcinomas, melanomas and leukemias cells. However, this protein is undetectable in the nucleus of any cell lines of nonmalignant cells or normal tissues, except for the testis. Expressed in the cytoplasm of all the proliferating cells, including normal and malignant cells, but not in normal tissues, except for the testis and the fetal liver.
  • Information by UniProt

References for Human SART3 peptide (ab45492)

ab45492 has not yet been referenced specifically in any publications.

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