Overview

  • Product name
    Human SCRIBBLE peptide

Description

  • Nature
    Synthetic
  • Amino Acid Sequence
    • Species
      Human
    • Sequence
      C-VRPGRRGLGPVPS
    • Amino acids
      1618 to 1630

Specifications

Our Abpromise guarantee covers the use of ab23149 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

General Info

  • Alternative names
    • CRIB 1
    • CRIB1
    • hScrib
    • LAP 4
    • LAP4
    • PDZ domain protein scribble
    • Protein LAP4
    • Protein scribble homolog
    • SCRB 1
    • SCRB1
    • Scrib
    • SCRIB 1
    • SCRIB_HUMAN
    • SCRIB1
    • Scribble
    • Scribble homolog 1
    • scribbled homolog (Drosophila)
    • Vartul
    see all
  • Function
    Scaffold protein involved in different aspects of polarized cells differentiation regulating epithelial and neuronal morphogenesis. Most probably functions in the establishment of apico-basal cell polarity. May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium. May also function in cell migration and adhesion and hence regulate cell invasion through MAPK signaling. May play a role in exocytosis and in the targeting synaptic vesicles to synapses. Functions as an activator of Rac GTPase activity.
  • Tissue specificity
    Expressed in kidney, skeletal muscles, liver, lung, breast, intestine, placenta and skin mainly in epithelial cells (at protein level).
  • Sequence similarities
    Belongs to the LAP (LRR and PDZ) protein family.
    Contains 16 LRR (leucine-rich) repeats.
    Contains 4 PDZ (DHR) domains.
  • Post-translational
    modifications
    Ubiquitinated; targeted for UBE3A-dependent multiubiquitination in the presence of high-risk HPV E6 proteins and degraded.
  • Cellular localization
    Cell membrane. Cell junction > adherens junction. Cytoplasm. Targeting to cell-cell junctions which is CDH1-dependent is required for the pro-apoptotic activity. Localizes to neuronal post- and pre-synaptic regions.
  • Information by UniProt

References for Human SCRIBBLE peptide (ab23149)

ab23149 has not yet been referenced specifically in any publications.

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