• Product nameHuman SDHA peptide


  • NatureSynthetic

Associated products


Our Abpromise guarantee covers the use of ab66483 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-SDHA antibody (ab66484)

  • Purity70 - 90% by HPLC.

  • FormLiquid
  • Additional notes

    - First try to dissolve a small amount of peptide in either water or buffer. The more charged residues on a peptide, the more soluble it is in aqueous solutions.
    - If the peptide doesn’t dissolve try an organic solvent e.g. DMSO, then dilute using water or buffer.
    - Consider that any solvent used must be compatible with your assay. If a peptide does not dissolve and you need to recover it, lyophilise to remove the solvent.
    - Gentle warming and sonication can effectively aid peptide solubilisation. If the solution is cloudy or has gelled the peptide may be in suspension rather than solubilised.
    - Peptides containing cysteine are easily oxidised, so should be prepared in solution just prior to use.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Information available upon request.

General Info

  • Alternative names
    • CMD1GG
    • Flavoprotein subunit of complex II
    • Fp
    • PGL5
    • SDH 2
    • SDH1
    • SDH2
    • SDHA
    • SDHF
    • Succinate dehydrogenase [ubiquinone] flavoprotein subunit
    • Succinate dehydrogenase [ubiquinone] flavoprotein subunit mitochondrial
    • Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
    • Succinate dehydrogenase complex flavoprotein subunit
    • Succinate dehydrogenase complex flavoprotein subunit A
    • Succinate dehydrogenase complex flavoprotein subunit precursor
    • Succinate dehydrogenase complex subunit A
    • Succinate dehydrogenase complex subunit A flavoprotein
    • Succinate dehydrogenase complex subunit A flavoprotein (Fp)
    see all
  • FunctionFlavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
  • PathwayCarbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.
  • Involvement in diseaseDefects in SDHA are a cause of mitochondrial complex II deficiency (MT-C2D) [MIM:252011]. A disorder of the mitochondrial respiratory chain with heterogeneous clinical manifestations. Clinical features include psychomotor regression in infants, poor growth with lack of speech development, severe spastic quadriplegia, dystonia, progressive leukoencephalopathy, muscle weakness, exercise intolerance, cardiomyopathy. Some patients manifest Leigh syndrome or Kearns-Sayre syndrome.
    Defects in SDHA are a cause of Leigh syndrome (LS) [MIM:256000]. LS is a severe disorder characterized by bilaterally symmetrical necrotic lesions in subcortical brain regions.
    Defects in SDHA are the cause of cardiomyopathy dilated type 1GG (CMD1GG) [MIM:613642]. CMD1GG is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
  • Sequence similaritiesBelongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.
  • Cellular localizationMitochondrion inner membrane.
  • Information by UniProt

References for Human SDHA peptide (ab66483)

ab66483 has not yet been referenced specifically in any publications.

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