Overview

Description

  • NatureSynthetic
  • Amino Acid Sequence
    • SpeciesHuman

Specifications

Our Abpromise guarantee covers the use of ab42770 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activityThe ab42770 peptide blocks antibodies that recognise amino acids in the C-terminal region of human Sema3A. This sequence has two amino acid differences from rat and mouse Sema3A, and has low homology to other semaphorin family members.
  • Applications

    Blocking

    ELISA

  • FormLiquid
  • Additional notesThe ab42770 peptide blocks antibodies that recognise amino acids in the C-terminal region of human Sema3A. This sequence has two amino acid differences from rat and mouse Sema3A, and has low homology to other semaphorin family members.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: 0.05% Sodium Azide
    Constituents: PBS

General Info

  • Alternative names
    • Coll 1
    • Coll1
    • HH16
    • Hsema I
    • Hsema III
    • Sema domain immunoglobulin domain (Ig) short basic domain secreted (semaphorin) 3A
    • Sema III
    • SEMA1
    • SEMA1-PEN
    • SEMA3A
    • SEMAD
    • SEMAIII
    • SEMAL
    • Semaphorin 3A precursor
    • Semaphorin III
    • Semaphorin like growth cone guidance homolog of chick collapsin
    • Semaphorin3A
    • SemD
    see all
  • RelevanceOne family of inhibitory axon guidance molecules is the semaphorins. The semaphorins include secreted, transmembrane, and GPI anchored extracellular molecules that are involved in regulating axon guidance by inhibiting axons from growing toward incorrect targets. Semaphorin 3A (Sema3A) may play a particularly interesting role in limiting axon regeneration since it is expressed in meningeal fibroblasts that invade the injured spinal cord and surround the glial scar. In addition, the Sema3A co receptors, Neuropilin 1 and Plexin A1, are expressed on axons that regenerate up to the injured region, but do not cross this Sema3A containing region. Thus, Sema3A and its co receptors may have important roles in regulating axon guidance during neuronal development and after neuronal injury.
  • Cellular localizationSecreted

References for Human Semaphorin 3A peptide (ab42770)

ab42770 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"