Overview

  • Product name
    Human SENP6 peptide

Description

  • Nature
    Synthetic
  • Amino Acid Sequence
    • Species
      Human
    • Sequence
      AAGKSGGSAGEIT-C
    • Amino acids
      2 to 14

Specifications

Our Abpromise guarantee covers the use of ab23114 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

General Info

  • Alternative names
    • 2810017C20Rik
    • FLJ11355
    • FLJ11887
    • KIAA0389
    • KIAA0797
    • SENP 6
    • Senp6
    • SENP6_HUMAN
    • Sentrin specific protease 6
    • Sentrin-specific protease 6
    • Sentrin/SUMO specific protease SENP6
    • Sentrin/SUMO-specific protease SENP6
    • SSP 1
    • SSP1
    • SUMO 1 specific protease
    • SUMO 1 specific protease 1
    • SUMO-1-specific protease 1
    • SUMO1 specific protease
    • SUMO1 specific protease 1
    • SUMO1/sentrin specific peptidase 6
    • SUSP 1
    • SUSP1
    see all
  • Function
    Protease that deconjugates SUMO1, SUMO2 and SUMO3 from targeted proteins. Processes preferentially poly-SUMO2 and poly-SUMO3 chains, but does not efficiently process SUMO1, SUMO2 and SUMO3 precursors. Deconjugates SUMO1 from RXRA, leading to transcriptional activation. Involved in chromosome alignment and spindle assembly, by regulating the kinetochore CENPH-CENPI-CENPK complex. Desumoylates PML and CENPI, protecting them from degradation by the ubiquitin ligase RNF4, which targets polysumoylated proteins for proteasomal degradation. Desumoylates also RPA1, thus preventing recruitment of RAD51 to the DNA damage foci to initiate DNA repair through homologous recombinaison.
  • Tissue specificity
    Highly expressed in reproductive organs, such as testis, ovary and prostate.
  • Pathway
    Protein modification; protein sumoylation.
  • Sequence similarities
    Belongs to the peptidase C48 family.
  • Cellular localization
    Nucleus.
  • Information by UniProt

References

ab23114 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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