Overview

Description

  • NatureSynthetic
  • Amino Acid Sequence
    • SpeciesHuman
    • SequenceKRFLEDTTDDGE amino acids 3 to 14 of human ARTS (1).
    • Amino acids3 to 14

Associated products

Specifications

Our Abpromise guarantee covers the use of ab9652 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-SEPT4 antibody (ab9651)

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    PBS with 0.1% BSA 0.02% sodium azide pH7.2

General Info

  • Alternative names
    • Apoptosis-related protein in the TGF-beta signaling pathway
    • ARTS
    • Bradeion
    • Bradeion beta
    • Brain protein H5
    • CE5B3
    • CE5B3 beta
    • Cell division control-related protein 2
    • Cerebral protein 7
    • H5
    • hCDCREL-2
    • hucep-7
    • MART
    • Peanut-like protein 2
    • PNUTL2
    • SEP 4
    • SEP4
    • Sept4
    • SEPT4_HUMAN
    • Septin M
    • Septin-4
    see all
  • FunctionFilament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in platelet secretion. Isoform ARTS, but not the other isoforms, is required for the induction of cell death mediated by TGF-beta and by other apoptotic stimuli.
  • Tissue specificityWidely expressed in adult and fetal tissues with highest expression in adult brain (at protein level), heart, liver and adrenal gland and fetal heart, kidney, liver and lung. Also expressed in colorectal cancers and malignant melanomas. Expressed in platelets.
  • Sequence similaritiesBelongs to the septin family.
  • Cellular localizationCytoplasm. Cytoplasm > cytoskeleton. In platelets, found in areas surrounding alpha-granules and Mitochondrion. Nucleus. While predominantly localized in the mitochondria under resting conditions, isoform ARTS translocates into the nucleus after TGF-beta treatment and apoptosis induction.
  • Information by UniProt

References for Human SEPT4 peptide (ab9652)

ab9652 has not yet been referenced specifically in any publications.

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