Overview

Description

  • NatureSynthetic
  • Amino Acid Sequence
    • SpeciesHuman
    • SequenceRWQKCVDCNGSYFD
    • Amino acids658 to 671

Associated products

Specifications

Our Abpromise guarantee covers the use of ab22960 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-SETMAR antibody (ab3823)

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

General Info

  • Alternative names
    • Histone lysine N methyltransferase
    • Histone lysine N methyltransferase SETMAR
    • Hsmar 1
    • Hsmar1
    • Mariner transposase Hsmar1
    • Metnase
    • SET domain and mariner transposase fusion
    • SET domain and mariner transposase fusion gene
    • SET domain and mariner transposase fusion gene containing protein
    • SET domain and mariner transposase fusion gene-containing protein
    • Setmar
    • SETMR_HUMAN
    see all
  • FunctionHistone methyltransferase that methylates 'Lys-4' and 'Lys-36' of histone H3, 2 specific tags for epigenetic transcriptional activation. Specifically mediates dimethylation of H3 'Lys-36'. Has sequence-specific DNA-binding activity and recognizes the 19-mer core of the 5'-terminal inverted repeats (TIRs) of the Hsmar1 element. Has DNA nicking activity. Has in vivo end joining activity and may mediate genomic integration of foreign DNA.
  • Tissue specificityWidely expressed, with highest expression in placenta and ovary and lowest expression in skeletal muscle.
  • Sequence similaritiesIn the N-terminal section; belongs to the histone-lysine methyltransferase family.
    In the C-terminal section; belongs to the mariner transposase family.
    Contains 1 post-SET domain.
    Contains 1 pre-SET domain.
    Contains 1 SET domain.
  • DomainThe mariner transposase Hsmar1 region mediates DNA-binding. It has no transposase activity because the active site contains an Asn in position 610 instead of a Asp residue.
  • Cellular localizationNucleus. Chromosome.
  • Information by UniProt

References for Human SETMAR peptide (ab22960)

ab22960 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"