Overview

Description

  • NatureSynthetic
  • Amino Acid Sequence
    • SpeciesHuman
    • SequenceC-QYPVEKKSSARSTQ
    • Amino acids99 to 112

Associated products

Specifications

Our Abpromise guarantee covers the use of ab50447 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-SH2D1A/SAP antibody (ab50422)

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

General Info

  • Alternative names
    • DSHP
    • Duncan disease SH2 protein
    • Duncan disease SH2-protein
    • EBVS
    • IMD5
    • LYP
    • MTCP1
    • SAP
    • SAP/SH2D1A
    • SH2 domain containing 1A
    • SH2 domain protein 1A
    • SH2 domain-containing protein 1A
    • SH21A_HUMAN
    • SH2D1A
    • Signaling lymphocyte activation molecule associated protein
    • Signaling lymphocytic activation molecule-associated protein
    • SLAM associated protein
    • SLAM associated protein/SH2 domain protein 1A
    • SLAM-associated protein
    • T cell signal transduction molecule SAP
    • T-cell signal transduction molecule SAP
    • XLP
    • XLPD
    see all
  • FunctionInhibitor of the SLAM self-association. Acts by blocking recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to a docking site in the SLAM cytoplasmic region. Mediates interaction between FYN and SLAMF1. May also regulate the activity of the neurotrophin receptors NTRK1, NTRK2 and NTRK3.
  • Tissue specificityExpressed at a high level in thymus and lung, with a lower level of expression in spleen and liver. Expressed in peripheral blood leukocytes, including T lymphocytes. Tends to be expressed at lower levels in peripheral blood leukocytes in patients with rheumatoid arthritis.
  • Involvement in diseaseDefects in SH2D1A are a cause of lymphoproliferative syndrome X-linked type 1 (XLP1) [MIM:308240]; also known as X-linked lymphoproliferative disease (XLPD) or Duncan disease. XLP is a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus (EBV). Symptoms include severe or fatal mononucleosis, acquired hypogammaglobulinemia, pancytopenia and malignant lymphoma.
  • Sequence similaritiesContains 1 SH2 domain.
  • Cellular localizationCytoplasm.
  • Information by UniProt

References for Human SH2D1A/SAP peptide (ab50447)

ab50447 has not yet been referenced specifically in any publications.

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