The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
SH2 domain containing adapter protein B
SH2 domain-containing adapter protein B
SHB (Src homology 2 domain containing) adaptor protein B
SHB adaptor protein
SHB adaptor protein (a Src homology 2 protein)
Src homology 2 domain containing adaptor protein B
Src homology 2 protein
FunctionAdapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. May play a role in angiogenesis by regulating FGFR1, VEGFR2 and PDGFR signaling. May also play a role in T-cell antigen receptor/TCR signaling, interleukin-2 signaling, apoptosis and neuronal cells differentiation by mediating basic-FGF and NGF-induced signaling cascades. May also regulate IRS1 and IRS2 signaling in insulin-producing cells.
Tissue specificityWidely expressed.
Sequence similaritiesContains 1 SH2 domain.
DomainThe SH2 domain preferentially binds phosphopeptides with the consensus sequence Y-[TVI]-X-L and mediates interaction with PDGFRA, PDGFRB, FGRFR1, IL2RB, IL2RG, CD3Z and CRK/CrKII.
Post-translational modificationsPhosphorylated upon PDGFRA, PDGFRB, TCR, IL2 receptor, FGFR1 or VEGFR2 activation.
Cellular localizationCytoplasm. Cell membrane. Associates with membrane lipid rafts upon TCR stimulation.