Overview

  • Product name
    Human SHB peptide

Description

  • Nature
    Synthetic
  • Amino Acid Sequence
    • Species
      Human
    • Sequence
      C-EHLSLLYPVAVRTL
    • Amino acids
      496 to 509

Specifications

Our Abpromise guarantee covers the use of ab22790 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

General Info

  • Alternative names
    • bA3J10.2
    • OTTHUMP00000021397
    • RP11 3J10.8
    • RP113J10.8
    • SH2 domain containing adapter protein B
    • SH2 domain-containing adapter protein B
    • Shb
    • SHB (Src homology 2 domain containing) adaptor protein B
    • SHB adaptor protein
    • SHB adaptor protein (a Src homology 2 protein)
    • SHB_HUMAN
    • Src homology 2 domain containing adaptor protein B
    • Src homology 2 protein
    see all
  • Function
    Adapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. May play a role in angiogenesis by regulating FGFR1, VEGFR2 and PDGFR signaling. May also play a role in T-cell antigen receptor/TCR signaling, interleukin-2 signaling, apoptosis and neuronal cells differentiation by mediating basic-FGF and NGF-induced signaling cascades. May also regulate IRS1 and IRS2 signaling in insulin-producing cells.
  • Tissue specificity
    Widely expressed.
  • Sequence similarities
    Contains 1 SH2 domain.
  • Domain
    The SH2 domain preferentially binds phosphopeptides with the consensus sequence Y-[TVI]-X-L and mediates interaction with PDGFRA, PDGFRB, FGRFR1, IL2RB, IL2RG, CD3Z and CRK/CrKII.
  • Post-translational
    modifications
    Phosphorylated upon PDGFRA, PDGFRB, TCR, IL2 receptor, FGFR1 or VEGFR2 activation.
  • Cellular localization
    Cytoplasm. Cell membrane. Associates with membrane lipid rafts upon TCR stimulation.
  • Information by UniProt

References

ab22790 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab22790.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

Sign up