Overview

  • Product nameHuman SHB peptide

Description

  • NatureSynthetic
  • Amino Acid Sequence
    • SpeciesHuman
    • SequenceC-EHLSLLYPVAVRTL
    • Amino acids496 to 509

Specifications

Our Abpromise guarantee covers the use of ab22790 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

General Info

  • Alternative names
    • bA3J10.2
    • OTTHUMP00000021397
    • RP11 3J10.8
    • RP113J10.8
    • SH2 domain containing adapter protein B
    • SH2 domain-containing adapter protein B
    • Shb
    • SHB (Src homology 2 domain containing) adaptor protein B
    • SHB adaptor protein
    • SHB adaptor protein (a Src homology 2 protein)
    • SHB_HUMAN
    • Src homology 2 domain containing adaptor protein B
    • Src homology 2 protein
    see all
  • FunctionAdapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. May play a role in angiogenesis by regulating FGFR1, VEGFR2 and PDGFR signaling. May also play a role in T-cell antigen receptor/TCR signaling, interleukin-2 signaling, apoptosis and neuronal cells differentiation by mediating basic-FGF and NGF-induced signaling cascades. May also regulate IRS1 and IRS2 signaling in insulin-producing cells.
  • Tissue specificityWidely expressed.
  • Sequence similaritiesContains 1 SH2 domain.
  • DomainThe SH2 domain preferentially binds phosphopeptides with the consensus sequence Y-[TVI]-X-L and mediates interaction with PDGFRA, PDGFRB, FGRFR1, IL2RB, IL2RG, CD3Z and CRK/CrKII.
  • Post-translational
    modifications
    Phosphorylated upon PDGFRA, PDGFRB, TCR, IL2 receptor, FGFR1 or VEGFR2 activation.
  • Cellular localizationCytoplasm. Cell membrane. Associates with membrane lipid rafts upon TCR stimulation.
  • Information by UniProt

References for Human SHB peptide (ab22790)

ab22790 has not yet been referenced specifically in any publications.

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