Overview

Description

  • Nature
    Synthetic
  • Amino Acid Sequence
    • Species
      Human
    • Modifications
      phospho S591

Associated products

Specifications

Our Abpromise guarantee covers the use of ab42772 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activity
    The ab42772 peptide blocks antibodies that recognise amino acids around phosphorylated serine 591 of human SHP1. This sequence is highly conserved in rat and mouse SHP1.
  • Applications

    Blocking - Blocking peptide for Anti-SHP1 (phospho S591) antibody (ab41436)

    ELISA

  • Form
    Liquid
  • Additional notes


    Tyrosine and serine phosphorylation regulate SHP1 activity. Serine phosphorylation at Ser-591 is mediated by PKC-alpha and leads to inhibition of phosphatase activity.

    The ab42772 peptide blocks antibodies that recognise amino acids around phosphorylated serine 591 of human SHP1. This sequence is highly conserved in rat and mouse SHP1.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: 0.05% Sodium Azide
    Constituents: PBS

General Info

  • Alternative names
    • 70Z-SHP
    • EC 3.1.3.48
    • HCP
    • HCPH
    • Hematopoietic cell phosphatase
    • Hematopoietic cell protein tyrosine phosphatase
    • Hematopoietic cell protein-tyrosine phosphatase
    • HPTP1C
    • Protein tyrosine phosphatase 1C
    • Protein tyrosine phosphatase non receptor type 6
    • Protein tyrosine phosphatase SHP1
    • Protein-tyrosine phosphatase 1C
    • protein-tyrosine phosphatase SHP 1
    • Protein-tyrosine phosphatase SHP-1
    • PTN6_HUMAN
    • PTP 1C
    • PTP-1C
    • PTP1C
    • Ptpn6
    • SH PTP 1
    • SH PTP1
    • SH-PTP1
    • SHP 1
    • SHP 1L
    • SHP1
    • SHP1L
    • tyrosine protein phosphatase non receptor type 6
    • Tyrosine-protein phosphatase non-receptor type 6
    see all
  • Function
    Plays a key role in hematopoiesis. This PTPase activity may directly link growth factor receptors and other signaling proteins through protein-tyrosine phosphorylation. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation.
  • Tissue specificity
    Isoform 1 is expressed in hematopoietic cells. Isoform 2 is expressed in non-hematopoietic cells.
  • Sequence similarities
    Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily.
    Contains 2 SH2 domains.
    Contains 1 tyrosine-protein phosphatase domain.
  • Post-translational
    modifications
    Phosphorylated on serine and tyrosine residues.
  • Cellular localization
    Cytoplasm. Nucleus. In neurons, translocates into the nucleus after treatment with angiotensin II.
  • Information by UniProt

Images

  • All lanes : Anti-SHP1 (phospho S591) antibody (ab41436)

    Lane 3 : human Jurkat cells treated with pervanadate (1 mM) for 30 min
    Lane 4 : human Jurkat cells treated with pervanadate (1 mM ( for 30 min) and exposed to lambda phosphatase
    Lane 5 : human Jurkat cells treated with pervanadate (1 mM) for 30 min with phospho-SHP1 (Ser-591) peptide
    Lane 6 : human Jurkat cells treated with pervanadate (1 mM) for 30 min with non-specific phospho-serine peptide

References

ab42772 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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