FunctionPlays a key role in hematopoiesis. This PTPase activity may directly link growth factor receptors and other signaling proteins through protein-tyrosine phosphorylation. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation.
Tissue specificityIsoform 1 is expressed in hematopoietic cells. Isoform 2 is expressed in non-hematopoietic cells.
Sequence similaritiesBelongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily. Contains 2 SH2 domains. Contains 1 tyrosine-protein phosphatase domain.
Post-translational modificationsPhosphorylated on serine and tyrosine residues.
Cellular localizationCytoplasm. Nucleus. In neurons, translocates into the nucleus after treatment with angiotensin II.
All lanes : Anti-SHP1 (phospho S591) antibody (ab41436)
Lane 3 : human Jurkat cells
treated with pervanadate (1 mM) for 30 min Lane 4 : human Jurkat cells
treated with pervanadate (1 mM ( for 30 min) and exposed to lambda
phosphatase Lane 5 : human Jurkat cells
treated with pervanadate (1 mM) for 30 min with phospho-SHP1
(Ser-591) peptide Lane 6 : human Jurkat cells
treated with pervanadate (1 mM) for 30 min with non-specific
References for Human SHP1 peptide (ab42772)
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