Human SHP1 peptide (ab42773)

General Info

• Alternative names
  • 70Z-SHP
  • EC 3.1.3.48
  • HCP

  • HCPH
  • Hematopoietic cell phosphatase
  • Hematopoietic cell protein tyrosine phosphatase
  • Hematopoietic cell protein-tyrosine phosphatase
  • HPTP1C
  • Protein tyrosine phosphatase 1C
  • Protein tyrosine phosphatase non receptor type 6
  • Protein tyrosine phosphatase SHP1
  • Protein-tyrosine phosphatase 1C
  • protein-tyrosine phosphatase SHP 1
  • Protein-tyrosine phosphatase SHP-1
  • PTN6_HUMAN
  • PTP 1C
  • PTP-1C
  • PTP1C
  • Ptpn6
  • SH PTP 1
  • SH PTP1
  • SH-PTP1
  • SHP 1
  • SHP 1L
  • SHP1
  • SHP1L
  • tyrosine protein phosphatase non receptor type 6
  • Tyrosine-protein phosphatase non-receptor type 6

  see all
• Function
  Plays a key role in hematopoiesis. This PTPase activity may directly link growth factor receptors and other signaling proteins through protein-tyrosine phosphorylation. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation.
• Tissue specificity
  Isoform 1 is expressed in hematopoietic cells. Isoform 2 is expressed in non-hematopoietic cells.
• Sequence similarities
  Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily.
  Contains 2 SH2 domains.
  Contains 1 tyrosine-protein phosphatase domain.
• Post-translational
  modifications
  Phosphorylated on serine and tyrosine residues.
• Cellular localization
  Cytoplasm. Nucleus. In neurons, translocates into the nucleus after treatment with angiotensin II.

• Target information above from: UniProt accession P29350 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt