Human SHP1 peptide (ab42773)

Biological activityThe ab42773 peptide blocks antibodies that recognise amino acids around phosphorylated tyrosine 536 of human SHP1. The sequence is highly conserved in rat and mouse SHP1.
Applications
Blocking - Blocking peptide for Anti-SHP1 (phospho Y536) antibody (ab41437)

ELISA
FormLiquid
Additional notes

SHP1 activity is regulated by both tyrosine and serine phosphorylation. Phosphorylation of Tyr-536 and Tyr-564 stimulates phosphatase activity and promotes interaction with Grb-2.
The ab42773 peptide blocks antibodies that recognise amino acids around phosphorylated tyrosine 536 of human SHP1. The sequence is highly conserved in rat and mouse SHP1.
Concentration information loading...

Preparation and Storage

Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Preservative: 0.05% Sodium Azide
Constituents: PBS

General Info

Alternative names
- 70Z-SHP
- EC 3.1.3.48
- HCP
- HCPH
- Hematopoietic cell phosphatase
- Hematopoietic cell protein tyrosine phosphatase
- Hematopoietic cell protein-tyrosine phosphatase
- HPTP1C
- Protein tyrosine phosphatase 1C
- Protein tyrosine phosphatase non receptor type 6
- Protein tyrosine phosphatase SHP1
- Protein-tyrosine phosphatase 1C
- protein-tyrosine phosphatase SHP 1
- Protein-tyrosine phosphatase SHP-1
- PTN6_HUMAN
- PTP 1C
- PTP-1C
- PTP1C
- Ptpn6
- SH PTP 1
- SH PTP1
- SH-PTP1
- SHP 1
- SHP 1L
- SHP1
- SHP1L
- tyrosine protein phosphatase non receptor type 6
- Tyrosine-protein phosphatase non-receptor type 6
see all
FunctionPlays a key role in hematopoiesis. This PTPase activity may directly link growth factor receptors and other signaling proteins through protein-tyrosine phosphorylation. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation.
Tissue specificityIsoform 1 is expressed in hematopoietic cells. Isoform 2 is expressed in non-hematopoietic cells.
Sequence similaritiesBelongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily.
Contains 2 SH2 domains.
Contains 1 tyrosine-protein phosphatase domain.
Post-translational
modificationsPhosphorylated on serine and tyrosine residues.
Cellular localizationCytoplasm. Nucleus. In neurons, translocates into the nucleus after treatment with angiotensin II.
Target information above from: UniProt accession P29350 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt

Human SHP1 peptide images

Western blot - SHP1 peptide (ab42773)

All lanes : Anti-SHP1 (phospho Y536) antibody (ab41437)

Lane 3 : human Jurkat cells treated with pervanadate (1 mM) for 30 min.
Lane 4 : human Jurkat cells treated with pervanadate (1 mM)for 30 min and exposed to alkaline phosphatase
Lane 5 : human Jurkat cells treated with pervanadate (1 mM) for 30 min. with phospho-SHP1 (Tyr-536) peptide (ab42773)

References for Human SHP1 peptide (ab42773)

ab42773 has not yet been referenced specifically in any publications.

Publishing research using ab42773? Please let us know so that we can cite the reference in this datasheet.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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Human SHP1 peptide (ab42773)

Overview

Description

Associated products

Specifications

Preparation and Storage

General Info

Human SHP1 peptide images

References for Human SHP1 peptide (ab42773)

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