Overview

Description

  • NatureSynthetic
  • Amino Acid Sequence
    • SpeciesHuman
    • SequenceC-EAIGYEYSEINIPK
    • Amino acids464 to 477

Specifications

Our Abpromise guarantee covers the use of ab23252 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

General Info

  • Alternative names
    • FLJ38600
    • S2V
    • sialic acid binding Ig-like lectin 12 (gene/pseudogene)
    • Sialic acid-binding Ig-like lectin 12
    • Sialic acid-binding Ig-like lectin-like 1
    • Sialic acid-binding immunoglobulin-like lectins
    • SIG12_HUMAN
    • Siglec-12
    • Siglec-L1
    • SIGLEC-like 1
    • SIGLEC-like gene
    • SIGLEC-like protein 1
    • Siglec-XII
    • Siglec12
    • SLG
    see all
  • FunctionPutative adhesion molecule that mediates sialic-acid dependent binding to cells. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.
  • Tissue specificityIsoform Short is highly expressed in spleen, small intestine and adrenal gland; it is lower expressed in thyroid, placenta, brain, stomach, bone marrow, spinal chord and breast. Isoform Long is highly expressed in spleen, small intestine and bone marrow; it is lower expressed in thyroid, placenta, thymus, trachea, stomach, lung, adrenal gland, fetal brain and testis.
  • Sequence similaritiesBelongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
    Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
    Contains 2 Ig-like V-type (immunoglobulin-like) domains.
  • DomainContains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
  • Cellular localizationMembrane.
  • Information by UniProt

References for Human SIGLECL1 peptide (ab23252)

ab23252 has not yet been referenced specifically in any publications.

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