Overview

Description

  • Nature
    Synthetic
  • Amino Acid Sequence
    • Species
      Human
    • Sequence
      C-ASKQLGSPTADLA
    • Amino acids
      1030 to 1042

Specifications

Our Abpromise guarantee covers the use of ab23193 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

General Info

  • Alternative names
    • GTPase activating protein Spa 1
    • GTPase-activating protein Spa-1
    • MGC102688
    • MGC17037
    • p130 SPA-1
    • p130 SPA1
    • Signal induced proliferation associated 1
    • Signal induced proliferation associated gene 1
    • Signal induced proliferation associated protein 1
    • Signal-induced proliferation-associated protein 1
    • SIPA 1
    • Sipa-1
    • Sipa1
    • SIPA1_HUMAN
    • Spa1
    see all
  • Function
    GTPase activator for the nuclear Ras-related regulatory proteins Rap1 and Rap2 in vitro, converting it to the putatively inactive GDP-bound state.
  • Tissue specificity
    Expressed in fetal as well as in adult tissues. Expressed abundantly in the lymphoid tissues such as thymus, spleen and peripheral blood lymphocytes and also shows a significant expression in the spinal cord.
  • Sequence similarities
    Contains 1 PDZ (DHR) domain.
    Contains 1 Rap-GAP domain.
  • Cellular localization
    Nucleus. Cytoplasm > perinuclear region. Endomembrane system. Mostly localized in the perinuclear membraneous region.
  • Information by UniProt

References

ab23193 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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